Data collection and analysis
Clinical data were extracted from the detailed documentation in the
database, including age of seizure onset, age at conception, residence,
education level, types of epilepsy before pregnancy, AED treatment
patterns in the first trimester, generalized tonic-clonic seizure (GTCS)
frequency during pregnancy, folic acid supplementation, and fetal
outcomes (induced abortion, SFL, live birth, preterm birth, cesarean
section, and MCM within one year of delivery). Clinical data were
reviewed and compared between the planned and unplanned pregnancy groups
by experienced epileptologists. The classification of epilepsy was in
accordance with the new 2017 International League Against Epilepsy
guideline.20 Appropriate folic acid supplementation
was defined as the use of folic acid from four weeks before to 12 weeks
after conception with a minimum daily dosage of 0.4
mg.12, 21