Conclusions
In conclusion, our study investigated the clinical characteristics and fetal outcomes of WWE in planned and unplanned pregnancy. We found that WWE with a planned pregnancy were associated with more optimized AED treatment patterns, better seizure control, more appropriate folic acid supplementation, and less fetal MCMs. Our study further verified the necessity and importance of pregnancy planning in the effective management of WWE of childbearing age. Further research with a larger sample size and comprehensive information on neonatal outcomes is necessary.
Acknowledgements: None.
Disclosure of Interests: None of the authors has any conflict of interest to disclose.
Contribution to authorship: YYZ had full access to all of the data in the study, conceived and designed the study, analysed and interpreted the data and drafted the manuscript. YYZ and CGS both contributed equally to the research study and manuscript. XW interpreted the data and revised the article. WJ conceived and designed the study, interpreted the data and revised the article. YLJ, JJZ, FY, XAY and FY interpreted the data and revised the article. All authors approved the final version.
Details of ethics approval: This study was approved by the Ethics Committee of Xijing Hospital (KY20163380 -1).
Funding: This study was supported by the National Natural Science Foundation of China (Grant Numbers 81771406 to Wen Jiang & Grant Numbers 81974204 to Wen Jiang).