Data collection and analysis
Clinical data were extracted from the detailed documentation in the database, including age of seizure onset, age at conception, residence, education level, types of epilepsy before pregnancy, AED treatment patterns in the first trimester, generalized tonic-clonic seizure (GTCS) frequency during pregnancy, folic acid supplementation, and fetal outcomes (induced abortion, SFL, live birth, preterm birth, cesarean section, and MCM within one year of delivery). Clinical data were reviewed and compared between the planned and unplanned pregnancy groups by experienced epileptologists. The classification of epilepsy was in accordance with the new 2017 International League Against Epilepsy guideline.20 Appropriate folic acid supplementation was defined as the use of folic acid from four weeks before to 12 weeks after conception with a minimum daily dosage of 0.4 mg.12, 21