Author’s contribution
W.Y.C., M.J.H.O., L.P. and A.H. designed the study. W.Y.C. and L.P.
conducted the experiment. L.P. carried out the laboratory work. J.C.,
W.Y.C. and A.H. undertook bioinformatic and statistical analyses. W.Y.C.
and M.J.H.O. wrote much of the manuscript and all authors contributed to
the final edited version of the manuscript.