Conclusion
Compared to continuation of magnesium for 24-hours postpartum, early
magnesium discontinuation postpartum does not significantly increase the
rate of postpartum eclampsia. The largest proportion of women did not
receive magnesium postpartum after receiving at least 8 grams
intrapartum, thus it is reasonable to consider discontinuation of
magnesium postpartum if a woman has received similar adequate dose prior
to delivery.Disclosure of interests : Dr. Ben Willem Mol is supported by a
NHMRC Practitioner Fellowship (GNT1082548). Dr. Ben Willem Mol reports
consultancy for ObsEva, Merck Merck KGaA and Guerbet. Dr Jack Ludmir and
Dr Paulino Vigil-de Gracia were both authors on included randomized
trials. The other authors did not report any potential conflicts of
interest.
Contribution to authorship : JQN, AdR, and VB were involved in
the conception of this meta-analysis. JQN, AdR, BM, EP, PVG, JL, LS and
LA were involved in the planning and carrying out of the project. JQN,
AdR performed the analysis and wrote the manuscript. The manuscript was
approved by all authors.
Details of ethics approval : This project was exempt from
Institutional Review Board.
Funding : No funding was used for this meta-analysis.
Acknowledgements: We would like to acknowledge Dr. Maryam
Kashanian, Dr Melania Amorim and Dr Sabina Maia who provided unpublished
data for inclusion in this meta-analysis.