Conclusion
Compared to continuation of magnesium for 24-hours postpartum, early magnesium discontinuation postpartum does not significantly increase the rate of postpartum eclampsia. The largest proportion of women did not receive magnesium postpartum after receiving at least 8 grams intrapartum, thus it is reasonable to consider discontinuation of magnesium postpartum if a woman has received similar adequate dose prior to delivery.Disclosure of interests : Dr. Ben Willem Mol is supported by a NHMRC Practitioner Fellowship (GNT1082548). Dr. Ben Willem Mol reports consultancy for ObsEva, Merck Merck KGaA and Guerbet. Dr Jack Ludmir and Dr Paulino Vigil-de Gracia were both authors on included randomized trials. The other authors did not report any potential conflicts of interest.
Contribution to authorship : JQN, AdR, and VB were involved in the conception of this meta-analysis. JQN, AdR, BM, EP, PVG, JL, LS and LA were involved in the planning and carrying out of the project. JQN, AdR performed the analysis and wrote the manuscript. The manuscript was approved by all authors.
Details of ethics approval : This project was exempt from Institutional Review Board.
Funding : No funding was used for this meta-analysis.
Acknowledgements: We would like to acknowledge Dr. Maryam Kashanian, Dr Melania Amorim and Dr Sabina Maia who provided unpublished data for inclusion in this meta-analysis.