Study Sample size of included women Countries of recruitment Blinded Intervention Comparator Primary outcome
Fontenot, 2005 98 (48 vs 50) United States of America No Received minimum of 2 hour magnesium therapy until the onset of diuresis (urine output >100 mL/hour for 2 consecutive hours) Magnesium for 24 hours postpartum NR
Ehrenberg, 2006 196 (101 vs 95) United States of America No 12 hours of postpartum magnesium Magnesium for 24 hours postpartum Duration of magnesium therapy
Darngawn, 2012 150 (75 vs 75) India No 6 hours - injections of magnesium were discontinued Magnesium injections for 24 hours postpartum NR
Maia, 2014
112 (56 vs 56)
Brazil
No
12 hours of postpartum magnesium
Magnesium for 24 hours postpartum
Duration of anticonvulsant therapy postpartum
Kashanian, 2016 170 (79 vs 91) Iran No 12 hours of postpartum magnesium Magnesium for 24 hours postpartum Convulsion
Rimal, 2017 60 (30 vs 30) Nepal No Loading dose of magnesium antepartum only Magnesium for 24 hours postpartum NR
Vigil-De Gracia, 2017 284 (141 vs 143) Panama No 6 hours of postpartum magnesium Magnesium for 24 hours postpartum Eclampsia in the first 72 hours postpartum
Vigil-De Gracia, 2018 1113 (558 vs 555) Dominican Republic, Ecuador, El Salvador, Panama, Peru No No magnesium sulfate postpartum Magnesium for 24 hours postpartum Eclampsia in the first 24 hours postpartum
Total:
2,183 (1,088 vs 1,095)
12 countries
8 non-blinded
1 – loading dose only a 1 – none postpartum 1 – until diuresis 2 – 6 hours 3 – 12 hours
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