Methods
Study
population
This study was conducted in theChildren’s Hospital of Chongqing Medical University (CHCMU).
CHCMU is one of two National Clinical Research Center for Child
Health and Disorders in China. The survey subjects are mainly medical
and scientific professionals in the hospital. And the survey is
voluntary.
Data
collection
A survey that focuses on knowledge, utilization and demand
of biobank was conducted online. We released an online questionnaire in
July 2019. The respondents filled out the items as required and submit
them online. Finally, a total of 182 valid questionnaires were
collected.
The questionnaire contains 32 questions in total, thirty of them are
multiple choice questions, and the other two are fill-in-the-blank
questions. The questions were grouped into four parts: (1) Demographic
information includes department, professional titles, education,
administrator and age. (2) Knowledge of the hospital’s biobank which
includes two parts. The first part is knowledge of biobank basic
information, mainly including geographic location, management situation
and WeChat public number of the biobank. The second part is knowledge of
the special project of clinical sample resources, mainly including
subsidy policy and sample warehousing process. Each part contains six
questions, and each question has two answers: Yes and No. One score will
be recorded when the answer is Yes, so the total score of each part is 6
scores, and the total score of all the two parts is 12 scores. (3)
Status of utilization of the hospital’s biobank, mainly including is
there a person responsible for the collection and processing of samples
in your biological sample project, do the samples currently collected by
yourself have quality assurance, do you regularly monitor the quality of
your samples. (4) Demand for the hospital’s biobank, including
willingness to pay to store samples in the hospital’s biobank, is it
acceptable to cost more than 5000 yuan per year for sample storage.
At the same time, we collected some indicators that can reflect the
development of clinical disciplines, including the participation
situation of National Natural Science Foundation of China (NSFC) and the
number of published English papers in different clinical disciplines in
the past five years (2014-2018). NSFC is the most common national fund
project in China, so it is included in this study.
In this study, clinical disciplines were divided into key disciplines
and non-key disciplines. And key disciplines are determined according to
the evaluation results of discipline construction of government
departments.
Data
analysis
SPSS 22.0 was used to complete data cleaning and analysis. Quantitative
data was described by mean and standard deviation, and was analyzed by
independent samples t test. But when the quantitative data did not
conform to normal distribution, the rank sum test was used. Qualitative
data was described by frequency and percentage, and was analyzed by
chi-square test.