Key Results
OCT2 and OCTN1 but not OCTN2 were involved in the uptake of OXA; OCT2 played the most important role. L-THP reduced the cytotoxicity and cellular accumulation of OXA in a concentration-dependent manner in MDCK-hOCT2, MDCK-hOCTN1, and rat primary DRG cells but did not affect its efflux from MDCK-hMRP2 cells. Furthermore, L-THP attenuated OXA-induced peripheral neurotoxicity and reduced the platinum concentration in the DRG in mice in a dose-dependent manner. L-THP did not reduce the platinum concentration in the tumours and did not impair the antitumour efficacy of OXA in HT29 tumour-bearing nude mice nor in tumour cells (HT29 and SW620 cells).