Background and Purpose
Oxaliplatin (OXA) is a third-generation anti-tumour platinum drug; however, the high accumulation of OXA in the dorsal root ganglia (DRG) induces severe peripheral neurotoxicity, which limits its application. This study aims to confirm the role of OCT2, OCTN1, and OCTN2 in the transcellular transport of OXA and to explore whether L-tetrahydropalmatine (L-THP) would selectively inhibit the uptake transporters and subsequently alleviate OXA-induced peripheral neurotoxicity.