Key Results
OCT2 and OCTN1 but not OCTN2 were involved in the uptake of OXA; OCT2
played the most important role. L-THP reduced the cytotoxicity and
cellular accumulation of OXA in a concentration-dependent manner in
MDCK-hOCT2, MDCK-hOCTN1, and rat primary DRG cells but did not affect
its efflux from MDCK-hMRP2 cells. Furthermore, L-THP attenuated
OXA-induced peripheral neurotoxicity and reduced the platinum
concentration in the DRG in mice in a dose-dependent manner. L-THP did
not reduce the platinum concentration in the tumours and did not impair
the antitumour efficacy of OXA in HT29 tumour-bearing nude mice nor in
tumour cells (HT29 and SW620 cells).