Conclusion and Implications
OCT2 and OCTN1, especially OCT2, contribute to OXA uptake in the DRG. L-THP attenuates OXA-induced peripheral neurotoxicity viainhibiting OCT2 and OCTN1 but without impairing the antitumour efficacy of OXA. L-THP is a potential candidate drug to attenuate OXA-induced peripheral neurotoxicity.