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    Abstract

    Leave the Abstract empty if your article falls under any of the following categories: Editorial Book Review, Commentary, Field Grand Challenge, Opinion or specialty Grand Challenge. As a primary goal, the abstract should render the general significance and conceptual advance of the work clearly accessible to a broad readership. References should not be cited in the abstract. Refer to http://www.frontiersin.org/ or Table \ref{Tab:01} for abstract requirement and length according to article type.

    Keywords: Text Text Text Text Text Text Text Text. All article types: you may provide up to 8 keywords; at least 5 are mandatory.

    Introduction

    Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text. Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text. Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text.Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text.

    Material & Methods

    Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text. (LastName1 2013) might want to know about text text text text Text Text Text Text Text Text Text Text Text Text Text Text. (OtherAuthor et al., 2012) might want to know about text text text text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text Text. (Author4 2013) might want to know about text text text text

    Maximum size of the Manuscript\label{Tab:01}
    Abstract max. legth (incl. spaces) Figures or tables Manuscript max. length Final PDF length
    Clinical Case Study
    Clinical Trial
    Hypothesis and Theory
    Methods 2000 characters 15 12000 words 12 pages
    Original Research
    Review
    Technology Report
    Focused Review 2000 characters 5 5000 words 5 pages
    CPC 1250 characters 6 2500 words 4 pages
    Perspective 1250 characters 2 3000 words 3 pages
    Mini Review
    Classification 1250 characters 10 2000 words 12 pages
    Editorial none none 1000 words 1 page
    Book review
    Frontiers Commentary none 1 1000 words 1 page
    General Commentary
    Field Grand Challenge
    Opinion none 1 2000 words 2 pages
    Specialty Grand Challenge

    Please note that very large tables (covering several pages) cannot be included in the final PDF for reasons of space. These tables will be published as supplementary material on the online article abstract page at the time of acceptance. The author will notified during the typesetting of the final article if this is the case. A link in the final PDF will direct to the online material.

    Original Research Articles, Clinical Trial Articles, and Technology Reports

    For Original Research Articles, Clinical Trial Articles, and Technology Reports the section headings should be those appropriate for your field and the research itself. It is recommended to organize your manuscript in the following sections or their equivalents for your field:

    • Introduction: Succinct, with no subheadings.

    • Materials and Methods: This section may be divided by subheadings. This section should contain sufficient detail so that when read in conjunction with cited references, all procedures can be repeated.

    • Results: This section may be divided by subheadings. Footnotes should not be used and have to be transferred into the main text.

    • Discussion: This section may be divided by subheadings. Discussions should cover the key findings of the study: discuss any prior art related to the subject so to place the novelty of the discovery in the appropriate context; discuss the potential short-comings and limitations on their interpretations; discuss their integration into the current understanding of the problem and how this advances the current views; speculate on the future direction of the research and freely postulate theories that could be tested in the future.

    Please note that the Material and Methods section can be placed in any of the following ways: before Results, before Discussion or after Discussion.

    Clinical Case Studies

    For Clinical Case Studies the following sections are mandatory:

    • Introduction: Include symptoms at presentation, physical exams and lab results.

    • Background: This section may be divided by subheadings. Include history and review of similar cases.

    • Results: This section may be divided by subheadings. Include diagnosis and treatment.

    • Concluding Remarks

    Results

    Frontiers requires figures to be submitted individually, in the same order as they are referred to in the manuscript. Figures will then be automatically embedded at the bottom of the submitted manuscript. Kindly ensure that each table and figure is mentioned in the text and in numerical order. Permission must be obtained for use of copyrighted material from other sources (including the web). Please note that it is compulsory to follow figure instructions. Figures which are not according to the guidelines will cause substantial delay during the production process.

    Resolution Requirements for the figures\label{Tab:02}
    Image Type Description Format Color Mode Resolution
    Line Art An image composed of lines and text, TIFF, JPEG RGB, Bitmap 900 - 1200 dpi
    which does not contain tonal or shaded areas.
    Halftone A continuous tone photograph, which contains no text. TIFF, EPS, JPEG RGB, Grayscale 300 dpi
    Combination Image contains halftone + text or line art elements. TIFF, JPEG RGB,Grayscale 600 - 900 dpi

    \[\sum x+ y =Z\label{eq:01}\]

    Table \ref{Tab:02} shows the resolution requirements for the figures. The figures must be legible:

    1. The smallest visible text is no less than 8 points in height, when viewed at actual size.

    2. Solid lines are not broken up.

    3. Image areas are not pixelated or stair stepped.

    4. Text is legible