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Symptoms of foliar nematodes on chrysanthemum. Foliar nematodes have relatively short life cycles going from egg to adult in approximately 2 weeks. Females can produce large numbers of eggs, so symptoms can occur and spread fairly rapidly. For a literature review, cf. Bik et al. (2009): Small worms big ideas: evolutionary inferences from nematode DNA. Journal of Biogeography, 37(1):2009. doi: 10.1111/j.1365-2699.2009.02219.x
But I must explain to you how all this mistaken idea of denouncing of a pleasure and praising pain was born and I will give you a complete account of the system, and expound the actual teachings of the great explorer of the truth, the master-builder of human happiness. No one rejects, dislikes, or avoids pleasure itself, because it is pleasure, but because those who do not know how to pursue pleasure rationally Pepe 2012encounter consequences that are extremely painful Fernando 2007. Nor again is there anyone who loves or pursues or desires to obtain pain of itself, because it is pain, but occasionally circumstances occur in which toil and pain can $$e=mc^2+r^4-\frac{\sqrt{r}}{s^4}$$ procure him some great pleasure. To take a trivial example, which of us ever undertakes laborious physical exercise, except to obtain some advantage from it? But who has any right to find fault with a man who chooses to enjoy a pleasure that has no annoying consequences, or one who avoids a pain that produces no resultant pleasure?
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[33] On the other hand, we denounce with righteous indignation and dislike men who are so beguiled and demoralized by the charms of pleasure of the moment, so blinded by desire, that they cannot foresee the pain and trouble that are bound to ensue Wagschal 2015; and equal blame belongs Colubri 2016 to those who fail in their duty through weakness of will, which is the same as saying through shrinking from toil and pain. These cases are perfectly simple and easy to distinguish. In a free hour, when our power of choice is untrammeled and when nothing prevents our being able to do what we like best, every pleasure is to be welcomed and every pain avoided Eadie 2016. But in certain circumstances and owing to the claims of duty or the obligations of business it will frequently occur that pleasures have to be repudiated and annoyances accepted. The wise man therefore always holds in these matters to this principle of selection: he rejects pleasures to secure other greater pleasures, or else he endures pains to avoid worse pains.

### References

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2. Michelle Fernando, Christine Stevens, Emily Walsh, Todd Green, Pardis Sabeti, John Rioux, Tim Vyse. Independent Signals Within the MHC are Associated with Systemic Lupus ErythematosusA Family-based SNP Study. Clinical Immunology 123, S99–S100 Elsevier BV, 2007. Link

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4. A Colubri, T Silver, T Fradet, K Retzepi, B Fry, P Sabeti. Transforming Clinical Data into Actionable Prognosis Models: Machine-Learning Framework and Field-Deployable App to Predict Outcome of Ebola Patients.. PLoS Negl Trop Dis 10, e0004549 (2016).

5. D Eadie, M Stead, AM MacKintosh, S Murray, C Best, J Pearce, C Tisch, der Sluijs W van, A Amos, A MacGregor, S Haw. Are Retail Outlets Complying with National Legislation to Protect Children from Exposure to Tobacco Displays at Point of Sale? Results from the First Compliance Study in the UK.. PLoS One 11, e0152178 (2016).