Figure 4. OGT2115 reduced apoptosis of islet beta cells in STZ
mice . (A) Insulin immunohistochemical staining, insulin (INS)/glucagon
(GCG) ratios, and TUNEL/insulin double-immunofluorescence staining in
islets administered with different doses of OGT2115. Nuclei were stained
with DAPI. Scale bar=50 μm. (B) Intensity of insulin immunohistochemical
staining based on islet area. (C) Ratio of insulin positive
(INS+) cells over glucagon positive
(GCG+) cells in the islets of the different treatment
groups. (D) Percentage of TUNEL/insulin positive cells over insulin
positive cells in the islets of the different treatment groups.
*p<0.05, **p<0.01, ***p<0.001, ns=not
significant as indicated, n=10.