Acknowledgements:
This work was supported by the National Natural Science Foundation (81420108007, 81603169, 81900703, and 81600598), the Natural Science Foundation of Jiangsu Province (BK20161027), the Natural Science Research Program for Higher Education in Jiangsu Province (16KJB310007), the Key Project of Science and Technology Development Fund of Nanjing Medical University (2015NJMUZD016), the China Postdoctoral Science Foundation Funded Project (2017M611869).