Main findings
Combination of NT-proBNP and sFlt-1 MoM improves prediction of
short-term delivery due to early-onset pre-eclampsia between those
pregnancies with an sFlt-1/PlGF ratio above 38, compared to higher
sFlt-1/PlGF ratio raw value cut-offs. We have built a prognostic
prediction calculator that is freely available at
http://sbpsoftware.com/peprogntool.
Repeated sFlt-1/PlGF ratio of 38 or below adequately rule out
early-onset pre-eclampsia leading to delivery within one week.
When sFlt-1/PlGF ratio is above 38, the addition of NT-proBNP has proven
superior to the use of sFlt-1/PlGF ratio as a single marker. Gestational
age-adjusted PlGF predictive ability is suboptimal and inferior than
gestational age-adjusted sFtl-1. Therefore, after selecting at risk
pregnancies using an sFlt-1/PlGF ratio cut-off of 38, repeated
determinations of sFlt-1/PlGF ratio and predictions based solely on this
marker cannot be recommended.