TABLE/FIGURE CAPTION LIST
Table 1: Comparison of binary test performance of the sFlt-1/PlGF ratio cut-off of 38 criteria and its combination with the prognostic prediction tool using all the included population, independently from sFlt-1/PlGF ratio value. Pregnancies with an sFlt-1/PlGF ratio of 38 or below have been considered as negative for the prognostic prediction tool. 95% CI: 95% confidence interval. DR: detection rate. FPR: false positive rate. PPV: positive predictive value. NPV: negative predictive value. PLR: positive likelihood ratio.
Figure 1: Inclusion-exclusion flow-chart.
Figure 2: Receiver operating characteristics (ROC) curve for median risk predictions of early-onset pre-eclampsia leading to delivery within one week in 123 women (213 samples) with suspected early-onset pre-eclampsia and an sFlt-1/PlGF ratio above 38, using a linear mixed model based on individual markers and gestational age (GA). Significant differences between AUC estimates of the sFlt-1 MoM model (solid line) and the PlGF MoM model (dashed line) were observed, referred to as A p-value (p< 0.001). While no differences were observed between the NT-proBNP (dotted line) and sFlt-1 MoM models, referred to as B p-value.
Figure 3: Receiver operating characteristics (ROC) curve for median risk predictions of early-onset pre-eclampsia leading to delivery within one week in 123 women (213 samples) with suspected early-onset pre-eclampsia and an sFlt-1/PlGF ratio above 38. The curves show the predictive performance of generalized linear mixed (GLM) models that combine gestational age (GA), and sFlt-1/PlGF ratio (left panel) and GA and sFlt-1 MoM (right panel) with NT-proBNP (solid line) and without NT-proBNP (dashed line). Vertical dashed red line indicates 5% false positive rate. Addition of NT-proBNP to both models significantly increases their predictive ability.