Figure 2. Reversal of the chemogenetic model of heart failure following drug treatments. A, Schematic showing timeline for induction of chemogenetic heart failure by AAV9-DAAO infection plus D-alanine feeding, followed by treatment of rats with the heart failure drugs sacubitril/valsartan or valsartan. B, Representative echocardiographic measurements in control or DAAO-infected rats, followed by treatments with sacubitril/valsartan or valsartan alone. C-D, Quantitative analyses of pooled data showing ejection fraction, left ventricular end diastolic volume and measurements of heart weight normalized to tibia length in DAAO-AAV9-infected animals following treatments as shown.