Disclosure of interest
The authors report no conflict of interest.
References
Azriel-Rosenfeld, R., Valensi, M., & Benhar, I. (2004). A human
synthetic combinatorial library of arrayable single-chain antibodies
based on shuffling in vivo formed CDRs into general framework regions.J Mol Biol, 335 (1), 177-192.
Barreiros dos Santos, M., Agusil, J. P., Prieto-Simon, B., Sporer, C.,
Teixeira, V., & Samitier, J. (2013). Highly sensitive detection of
pathogen Escherichia coli O157:H7 by electrochemical impedance
spectroscopy. Biosens Bioelectron, 45 , 174-180.
doi:10.1016/j.bios.2013.01.009
Baruch, K., Gur-Arie, L., Nadler, C., Koby, S., Yerushalmi, G.,
Ben-Neriah, Y., . . . Rosenshine, I. (2011). Metalloprotease type III
effectors that specifically cleave JNK and NF-kappaB. EMBO J,
30 (1), 221-231.
Bhavsar, A. P., Guttman, J. A., & Finlay, B. B. (2007). Manipulation of
host-cell pathways by bacterial pathogens. Nature, 449 (7164),
827-834. doi:10.1038/nature06247
Burnham, C. A., & Carroll, K. C. (2013). Diagnosis of Clostridium
difficile infection: an ongoing conundrum for clinicians and for
clinical laboratories. Clin Microbiol Rev, 26 (3), 604-630.
doi:10.1128/cmr.00016-13
Coburn, B., Sekirov, I., & Finlay, B. B. (2007). Type III secretion
systems and disease. Clin Microbiol Rev, 20 (4), 535-549.
doi:10.1128/cmr.00013-07
Cornelis, G. R. (2006). The type III secretion injectisome. Nat
Rev Microbiol, 4 (11), 811-825. doi:10.1038/nrmicro1526
Cox, L. M., & Blaser, M. J. (2015). Antibiotics in early life and
obesity. Nat Rev Endocrinol, 11 (3), 182-190.
doi:10.1038/nrendo.2014.210
Croxen, M. A., Law, R. J., Scholz, R., Keeney, K. M., Wlodarska, M., &
Finlay, B. B. (2013). Recent advances in understanding enteric
pathogenic Escherichia coli . Clin Microbiol Rev, 26 (4),
822-880.
Dekker, J. P., & Frank, K. M. (2015). Salmonella, Shigella, and
Yersinia. Clin Lab Med, 35 (2), 225-246.
Deng, W., Li, Y., Hardwidge, P. R., Frey, E. A., Pfuetzner, R. A., Lee,
S., . . . Finlay, B. B. (2005). Regulation of type III secretion
hierarchy of translocators and effectors in attaching and effacing
bacterial pathogens. Infect Immun, 73 (4), 2135-2146.
Deng, W., Marshall, N. C., Rowland, J. L., McCoy, J. M., Worrall, L. J.,
Santos, A. S., . . . Finlay, B. B. (2017). Assembly, structure, function
and regulation of type III secretion systems. Nat Rev Microbiol,
15 (6), 323-337. doi:10.1038/nrmicro.2017.20
Deng, W., Puente, J. L., Gruenheid, S., Li, Y., Vallance, B. A.,
Vazquez, A., . . . Finlay, B. B. (2004). Dissecting virulence:
systematic and functional analyses of a pathogenicity island. Proc
Natl Acad Sci U S A, 101 (10), 3597-3602. doi:10.1073/pnas.0400326101
Dickey, S. W., Cheung, G. Y. C., & Otto, M. (2017). Different drugs for
bad bugs: antivirulence strategies in the age of antibiotic resistance.Nat Rev Drug Discov, 16 (7), 457-471. doi:10.1038/nrd.2017.23
DiGiandomenico, A., Keller, A. E., Gao, C., Rainey, G. J., Warrener, P.,
Camara, M. M., . . . Stover, C. K. (2014). A multifunctional bispecific
antibody protects against Pseudomonas aeruginosa . Sci
Transl Med, 6 (262), 262ra155. doi:10.1126/scitranslmed.3009655
Domenech, M., Sempere, J., de Miguel, S., & Yuste, J. (2018).
Combination of Antibodies and Antibiotics as a Promising Strategy
Against Multidrug-Resistant Pathogens of the Respiratory Tract.Front Immunol, 9 , 2700. doi:10.3389/fimmu.2018.02700
Espy, M. J., Uhl, J. R., Sloan, L. M., Buckwalter, S. P., Jones, M. F.,
Vetter, E. A., . . . Smith, T. F. (2006). Real-time PCR in clinical
microbiology: applications for routine laboratory testing. Clin
Microbiol Rev, 19 (1), 165-256. doi:10.1128/cmr.19.1.165-256.2006
Felts, A. G., Grainger, D. W., & Slunt, J. B. (2000). Locally delivered
antibodies combined with systemic antibiotics confer synergistic
protection against antibiotic-resistant burn wound infection. J
Trauma, 49 (5), 873-878. doi:10.1097/00005373-200011000-00014
Fournier, P. E., Drancourt, M., Colson, P., Rolain, J. M., La Scola, B.,
& Raoult, D. (2013). Modern clinical microbiology: new challenges and
solutions. Nat Rev Microbiol, 11 (8), 574-585.
doi:10.1038/nrmicro3068
Frankel, G., Phillips, A. D., Rosenshine, I., Dougan, G., Kaper, J. B.,
& Knutton, S. (1998). Enteropathogenic and enterohaemorrhagicEscherichia coli : more subversive elements. Mol Microbiol,
30 (5), 911-921. doi:10.1046/j.1365-2958.1998.01144.x
Gauthier, A., Puente, J. L., & Finlay, B. B. (2003). Secretin of the
enteropathogenic Escherichia coli type III secretion system requires
components of the type III apparatus for assembly and localization.Infect Immun, 71 (6), 3310-3319.
Guttikonda, S., Tang, X. L., Yang, B. M., Armstrong, G. D., & Suresh,
M. R. (2007). Monospecific and bispecific antibodies against E. coli
O157 for diagnostics. J Immunol Methods, 327 (1-2), 1-9.
doi:10.1016/j.jim.2007.06.010
Hernando-Amado, S., Coque, T. M., Baquero, F., & Martinez, J. L.
(2019). Defining and combating antibiotic resistance from One Health and
Global Health perspectives. Nat Microbiol, 4 (9), 1432-1442.
doi:10.1038/s41564-019-0503-9
Iguchi, A., Thomson, N. R., Ogura, Y., Saunders, D., Ooka, T.,
Henderson, I. R., . . . Frankel, G. (2009). Complete genome sequence and
comparative genome analysis of enteropathogenic Escherichia coliO127:H6 strain E2348/69. J Bacteriol, 191 (1), 347-354.
Jiang, X., Ellabaan, M. M. H., Charusanti, P., Munck, C., Blin, K.,
Tong, Y., . . . Lee, S. Y. (2017). Dissemination of antibiotic
resistance genes from antibiotic producers to pathogens. Nat
Commun, 8 , 15784.
Joung, C. K., Kim, H. N., Lim, M. C., Jeon, T. J., Kim, H. Y., & Kim,
Y. R. (2013). A nanoporous membrane-based impedimetric immunosensor for
label-free detection of pathogenic bacteria in whole milk. Biosens
Bioelectron, 44 , 210-215. doi:10.1016/j.bios.2013.01.024
Kaper, J. B., Nataro, J. P., & Mobley, H. L. (2004). Pathogenic
Escherichia coli. Nat Rev Microbiol, 2 (2), 123-140.
doi:10.1038/nrmicro818
Khalil, I. A., Troeger, C., Blacker, B. F., Rao, P. C., Brown, A.,
Atherly, D. E., . . . Reiner, R. C., Jr. (2018). Morbidity and mortality
due to shigella and enterotoxigenic Escherichia coli diarrhoea: the
Global Burden of Disease Study 1990-2016. Lancet Infect Dis,
18 (11), 1229-1240.
Kujat Choy, S. L., Boyle, E. C., Gal-Mor, O., Goode, D. L., Valdez, Y.,
Vallance, B. A., & Finlay, B. B. (2004). SseK1 and SseK2 are novel
translocated proteins of Salmonella enterica serovar typhimurium.Infect Immun, 72 (9), 5115-5125.
Laxminarayan, R., Duse, A., Wattal, C., Zaidi, A. K., Wertheim, H. F.,
Sumpradit, N., . . . Cars, O. (2013). Antibiotic resistance-the need for
global solutions. Lancet Infect Dis, 13 (12), 1057-1098.
doi:10.1016/s1473-3099(13)70318-9
Laxminarayan, R., & Heymann, D. L. (2012). Challenges of drug
resistance in the developing world. Bmj, 344 , e1567.
doi:10.1136/bmj.e1567
Legler, P. M., Compton, J. R., Hale, M. L., Anderson, G. P., Olson, M.
A., Millard, C. B., & Goldman, E. R. (2017). Stability of isolated
antibody-antigen complexes as a predictive tool for selecting toxin
neutralizing antibodies. MAbs, 9 (1), 43-57.
Leslie, J. L., & Young, V. B. (2015). The rest of the story: the
microbiome and gastrointestinal infections. Curr Opin Microbiol,
23 , 121-125. doi:10.1016/j.mib.2014.11.010
Levin, B. R., Baquero, F., & Johnsen, P. J. (2014). A model-guided
analysis and perspective on the evolution and epidemiology of antibiotic
resistance and its future. Curr Opin Microbiol, 19 , 83-89.
doi:10.1016/j.mib.2014.06.004
Luo, W., & Donnenberg, M. S. (2006). Analysis of the function of
enteropathogenic Escherichia coli EspB by random mutagenesis.Infect Immun, 74 (2), 810-820.
Luo, W., & Donnenberg, M. S. (2011). Interactions and predicted host
membrane topology of the enteropathogenic Escherichia colitranslocator protein EspB. J Bacteriol, 193 (12), 2972-2980.
Luo, W., & Donnenberg, M. S. x. (2011). Interactions and predicted host
membrane topology of the enteropathogenic Escherichia coli translocator
protein EspB. J Bacteriol, 193 (12), 2972-2980.
Mills, S. D., & Finlay, B. B. (1994). Comparison of Salmonella typhi
and Salmonella typhimurium invasion, intracellular growth and
localization in cultured human epithelial cells. Microb Pathog,
17 (6), 409-423. doi:10.1006/mpat.1994.1086
Modi, S. R., Collins, J. J., & Relman, D. A. (2014). Antibiotics and
the gut microbiota. J Clin Invest, 124 (10), 4212-4218.
doi:10.1172/JCI72333
Munguia, J., & Nizet, V. (2017). Pharmacological Targeting of the
Host-Pathogen Interaction: Alternatives to Classical Antibiotics to
Combat Drug-Resistant Superbugs. Trends Pharmacol Sci, 38 (5),
473-488. doi:10.1016/j.tips.2017.02.003
Nizet, V. (2015). Stopping superbugs, maintaining the microbiota.Sci Transl Med, 7 (295), 295ed298.
doi:10.1126/scitranslmed.aab2373
O’Neill, J. (2016). Review on antibacterial resistance: tackling
drug-resistant infections globally. .
https://amr-review.org/sites/default/files/160518_Final%20paper_with%20cover.pdf;
accessed 4 January 2010
Theriot, C. M., Koenigsknecht, M. J., Carlson, P. E., Jr., Hatton, G.
E., Nelson, A. M., Li, B., . . . Young, V. B. (2014). Antibiotic-induced
shifts in the mouse gut microbiome and metabolome increase
susceptibility to Clostridium difficile infection. Nat Commun, 5 ,
3114. doi:10.1038/ncomms4114
Ventola, C. L. (2015). The antibiotic resistance crisis: part 1: causes
and threats. P t, 40 (4), 277-283.
Vermeer, A. W., & Norde, W. (2000). The thermal stability of
immunoglobulin: unfolding and aggregation of a multi-domain protein.Biophys J, 78 (1), 394-404.
Wolff, C., Nisan, I., Hanski, E., Frankel, G., & Rosenshine, I. (1998).
Protein translocation into host epithelial cells by infecting
enteropathogenic Escherichia coli. Mol Microbiol, 28 (1), 143-155.
Zhang, Y., Sun, X., Qian, Y., Yi, H., Song, K., Zhu, H., . . . Wu, D.
(2019). A potent anti-SpuE antibody allosterically inhibits type III
secretion system and attenuates virulence of Pseudomonas aeruginosa.J Mol Biol . doi:10.1016/j.jmb.2019.10.026