Neuroblastoma
Neuroblastoma starts in early forms of nerve cells found in a developing embryo or fetus. About 6% of childhood cancers are neuroblastomas. This type of cancer develops in infants and young children. It is rarely found in children older than 10. The tumor can start anywhere but usually starts in the belly (abdomen) where it is noticed as swelling. It can also cause bone pain and fever.
Introduction
Clinical heterogeneity has been thought to be a norm rather than an exception in many diseases -which indicates how different deregulated genetic pathways may lead to the same disease. Although many of previous studies[1-19] on the disease spectrum in pediatric AML/ALL and brain tumors have considerably focused on characterization of disease progression and targeted therapy, little has been known how abnormal patterns identified by super machinery Seq-based platforms explicitly work at cellular, molecular, organism al and functional level in personalized medicine as the causal and consequent effects. A better understanding of each part of genetic or genomic susceptibility and their ensemble contributors such as gene fusions and disease specific epigenetic modification will enable to more precisely uncover the complexity of pediatric tumorigenesis and target novel treatments.