Determining the genes carrying 5hmC modifications and its selective variation will open up new therapeutic targets. This review outlines the role of global and locus-specific changes of 5hmC in cancers and the possible mechanisms underlying such changes. We have described major cellular factors that influence 5hmC levels and highlighted the significance of 5hmC in tumor micro environmental condition like hypoxia.
Genomics landscape of pediatric cancers
http://kidsgenomics.org/genomic-landscape-pediatric-cancers/
Two consortium-led studies published last month in the journal Nature offer the most comprehensive surveys to-date of pediatric cancer genomes.
https://www.nature.com/articles/nature25480