<div>This is a caption</div>


<div>
<b>Section 2: Framing developmental impacts of the amygdala</b>
(CHARGE: Sketches of the amygdala’s postnatal developmental trajectory
(to underscore that this might create a window of vulnerability for the
effects of stress).</div>


<ul>
<li> 

Typical amygdala development includes a period of linear growth
throughout childhood and adolescence (Giedd et al, 1996; Schumann et
al, 2004; Nacewicz et al, 2006), although not significant in all
studies (Caviness et al, 1996). Amygdala volume likely follows a
nonlinear developmental trajectory, similar to overall cortical
development (Shaw et al, 2006). In agreement with this, a
meta-analysis of amygdala volume in adults found decreasing volume
with age (Brierley et al, 2002); this is corroborated by findings from
two large studies of individuals within the range of 15-90 y (Allen et
al, 2005; Walhovd et al, 2005). In these studies, and in a
stereological study of post-mortem tissues (Schumann &amp; Amaral, 2005),
largest amygdala volumes occurred between years 20 and 30. These
cross-sectional studies suggest a nonlinear pattern of amygdala
development that peaks late in the third decade of life in typically
developing individuals.
</li>
<li> 

In addition, let’s think about the developmental forces that shape the
amygdala–
</li>
<li> 

Attachment (Regina Sullivan, Regina Sullivan, Regina Sullivan)
</li>
<li> 

The HPA axis… cortisol is mostly bad, but it’s complicated
</li>
</ul>


<div>
<b>Section 3: Looking at past work on Early Adversity &amp; the
Amygdala </b> (CHARGE: Highlight the larger volumes that are *typically*
seen in young/pediatric samples; note the smaller volumes often seen in
adult samples; highlight a few very ‘contradictory results’ to push the
allostasis idea)</div>


<ul>
<li> 

… A good deal of this has already been composed for the
<i>failed</i> Biological review …
</li>
<li> 

Preclinical Work (important cites – Vyas &amp; Chattarji; Rosenkranz;
Important to note that much of this work has been completed in adult
animals. Rosenkranz used younger animals and the patterns are more
complex)
</li>
<li> 

Other (newer) pre-clinical work? [<b>Might be important things
to re-survey the literature</b> ]
</li>
</ul>