Figure 1. (a–b) Dendrimersomes load higher concentration of hydrophobic molecules compared to stealth liposomes representative confocal images of (a) onion-like and (b) unilamellar vesicles considered for the quantification of the loading efficiency of BODIPY. Stealth liposomes (SL) consisting of cholesterol (6.2 mg/mL), HSPC (8.9 mg/mL), mPEG-DSPE (0.8 mg/mL) and 0,01mg/mL 18:1 Rho-Liss-PE. (c) The histogram corresponds to the total loading of BODIPY in unilamellar and onion-like dendrimersomes and stealth liposomes. (e) Dendrimersomes are not amenable for the loading hydrophilic molecules. Representative confocal images of dendrimersomes and stealth liposomes loading HPTS(b). (f) The histogram shows that onion-vesicles made of dendrimers load poorly HPTS compared to stealth liposomes. (g–f) Dendrimersomes load higher concentration of doxorubicin compared to stealth liposomes.