H2-mediated microbes are inhibited by the low solubility of H2, and EET-mediated microbes may be able to offer an advantage of being able to overcome its electron transport through nanowires, being able to receive electrons directly.
Although EET-mediated synthetic schemes showed the lower thermionic efficiency rather than H2- mediated hybrid photosynthesis in the situation where variables were kept at standard levels but may benefit from being able to practicably be concentrated in a comparatively smaller cross-sectional area at a comparatively small cost in thermionic efficiencies. Also, the results indicated that fine-tuning the thermodynamics and improving kinetics in each module could pave a way to reduce the losses of efficiency, as all schemes seem to have the potential to exceed natural photosynthesis.