Addressing inappropriate antibiotic prescriptions requires a major cultural change of both those prescribing them and those receiving them. As for despite the alarming increase in antimicrobial resistance
Paul Ehlrich - coined the term chemotherapy -  and defined it as the use of chemicals to treat disease.  Also was the first to develop an animal model to screen the potential of chemicals against diseases \cite{DeVita2008}.
DHFR inhibitors
First successful chemotherapeutic agent - methotrexate \cite{DeVita2008} ,DHFR inhibitor, trimethoprim does the same.
Antifungal & Anti Cancers
Flucytosine (5FC)