| Variables |
Down-trending |
Stable |
Up-trending |
pValue |
| Number of patients |
979 |
674 |
876 |
|
| Black — n (%) |
61 (6.2) |
41 (6.1) |
48 (5.5) |
0.777 |
| Male — n(%) |
469 (47.9) |
336 (49.9) |
433 (49.4) |
0.695 |
| Peripheral Vascular Disease — n(%) |
318 (32.5) |
248 (36.8) |
323 (36.9) |
0.082 |
| Dementia (%) |
79 (8.1) |
61 (9.1) |
79 (9.0) |
0.703 |
| Pulmonary disease (%) |
719 (73.4) |
471 (69.9) |
643 (73.4) |
0.211 |
| Diabetes mellitus (%) |
205 (20.9) |
147 (21.8) |
223 (25.5) |
0.055 |
| Diabetes mellitus with complications (%) |
213 ( 21.8) |
138 (20.5) |
167 (19.1) |
0.357 |
| Cancer (%) |
143 ( 14.6) |
104 (15.4) |
144 (16.4) |
0.552 |
| Liver disease- (%) |
29 (3.0) |
21 (3.1) |
28 (3.2) |
0.957 |
| Metastatic malignancy (%) |
67 (6.8) |
31 (4.6) |
54 (6.2) |
0.164 |
| HIV (%) |
3 (0.3) |
1 (0.1) |
7 (0.8) |
0.115 |
| Liver disease- Mild (%) |
145 (14.8) |
89 (13.2) |
106 (12.1) |
0.227 |
| CHF (%) |
979 (100.0) |
674 (100.0) |
876 (100.0) |
NA |
| DHF (%) |
461 (47.1) |
359 (53.3) |
447 (51.0) |
0.038 |
| SHF (%) |
333 (34.0) |
197 (29.2) |
280 (32.0) |
0.122 |
| mixed (%) |
185 (18.9) |
118 (17.5) |
149 (17.0) |
0.547 |
| Ischemic heart disease (%) |
701 (71.6) |
480 ( 71.2) |
660 (75.3) |
0.11 |
| Valvular heart (%) |
595 ( 60.8) |
431 ( 63.9) |
514 (58.7) |
0.108 |
| Cardiomyopathy = TRUE (%) |
491 (50.2) |
275 ( 40.8) |
383 (43.7) |
<0.001 |
| Initial NT-proBNP (median [IQR]) |
4620.00 [2090.00, 10050.00] |
3410.00 [1482.50, 7060.00] |
2380.00 [774.00, 5045.00] |
<0.001 |
| Final NT-proBNP (median [IQR]) |
1630.00 [627.00, 3815.00] |
3140.00 [1427.50, 6780.00] |
5470.00 [2417.50, 12225.00] |
<0.001 |
| Age(years,mean (sd)) |
71.94 (14.71) |
76.31 (13.06) |
75.61 (13.43) |
<0.001 |
| Serum albumin (mean (sd)) |
3.77 (0.51) |
3.79 (0.57) |
3.80 (0.52) |
0.36 |
| Serum creatinine (median [IQR]) |
1.03 [0.80, 1.38] |
1.05
[0.84, 1.37] |
1.05 [0.82, 1.38] |
0.643 |
| Maximum ejection fraction (%, mean (sd)) |
49.39 (15.16) |
50.30
(14.66) |
49.91 (15.02) |
0.469 |
| Minimum ejection fraction (%, mean (sd)) |
40.59 (17.35) |
42.91
(16.27) |
42.04 (16.38) |
0.017 |
| Charlson comorbidity score (mean (sd)) |
4.94 (2.26) |
4.78 (2.23) |
4.95 (2.08) |
0.231 |
| Systolic blood pressure (mmHG,mean (sd)) |
124.34 (22.77) |
124.11
(22.59) |
123.16 (21.81) |
0.5 |
| Diastolic blood pressure (mean (sd)) |
71.87 (14.57) |
71.61 (15.06) |
69.54 (13.84) |
0.001 |
| Death within 6 months= TRUE (%) |
70 (7.2) |
90 (13.4) |
203 (23.2) |
<0.001 |
| Initial weight (mean (sd)) |
188.50 (57.56) |
186.85 (55.11) |
185.48
(58.52) |
0.523 |
| Change in weight through the study (mean (sd)) |
-0.58 (0.20) |
- 0.02
(0.14) |
+3.38 (20.58) |
<0.001 |
| Number of days between the first and last NT-proBNP (mean (sd)) |
67.65
(57.84) |
60.82 (57.54) |
73.25 (57.10) |
<0.001 |
| Number of NT-proBNP measurements per patient (mean (sd)) |
3.36 (1.84) |
3.07 (1.65) |
3.45 (2.07) |
<0.001 |
| Maximum number of days between consecutive NT-proBNP measurements per
patient (mean (sd)) |
52.04 (47.13) |
48.26 (47.33) |
58.33 (48.68) |
<0.001 |