, cosine similarity between FCD patches was significantly higher ($0.40\pm 0.26$) than between FCD and HV patches at any location (FCD and homotopic patches $cos=0.00\pm 0.30$, $p<0.001$, $d=1.40$, FCD and heterotopic patches $cos=0.00\pm 0.28$, $p<0.001$, $d=1.44$, with no difference between the two, $p=0.54$, $d=0.01$) (Figure S3).  Local normalization, therefore, not only aids with global outlier detection by decreasing the "outlierness" of normal cortical regions, but also with local outlier detection, by further distancing FCDs from the expected appearance in their homotopic regions.