I still need to do some stats to see the chances of 4 kids having CNVs in that gene, but they were not all affected kids, so it's not as exciting. It becomes a bit more interesting if we think of combinations of genes. For example, say you're in trouble if you have two (or more) disrupted of the genes in this list. Figure \ref{630579} dives into the first 7 rows in figure \ref{333900}: