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Iridium-Catalyzed, Intermolecular Hydroetherification of Unactivated Aliphatic Alkenes with Phenols
  • +2
  • Vuk Uskokovic,
  • Ashlie Lee,
  • Awaiting Activation,
  • Steven Sturlis,
  • Matthew Martz
Vuk Uskokovic

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Ashlie Lee
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Awaiting Activation
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Steven Sturlis
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Matthew Martz
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Abstract

Metal-catalyzed addition of an O–H bond to an alkene is a desirable process because it allows for rapid access to ethers from abundant starting materials without the formation of waste, without rearrangements, and with the possibility to control the stereoselectivity. We report the intermolecular, metal-catalyzed addition of phenols to unactivated α-olefins. Mechanistic studies of this rare catalytic reaction revealed a dynamic mixture of resting states that undergo O–H bond oxidative addition and subsequent olefin insertion to form ether products.