This week in science (#40)

Dusty Cosmology

Recent results from the European satellite Planck have challenged what was previously reported as the discovery of the century. The signal detected by BICEP2, a South Pole based experiment, and attributed to an extremely rapid expansion during the first moments of the Universe (inflation), seems to have a much simpler explanation: dust. While the judge is still out, and the absence of evidence is not evidence of absence, any extraordinary claims about the very first instants of the Universe will have to be backed by extraordinary proof.

Read more : Authorea Blog Post “First Evidence of Quantum Gravity?”
Read more : NY Times
Read more (Technical): Planck Scientific Article

Do Black Holes exist?

In a press release boldly entitled “Rethinking the Origins of the Universe” it is claimed that scientist Laura Merisini-Houghton has “proven, mathematically, that black holes can never come into being in the first place”. The reason being the inclusion of quantum effects (namely Hawking radiation) in the process of stellar mass Black Hole formation. This process is usually only discussed in the framework of Einstein’s general relativity. The press release has been criticized for a number of reasons: overhyping a result that is not peer-reviewed yet, generalizing the result to all kinds of black holes, and finally extending the implications of the finding to the first moments of the Universe (a topic that is not discussed in the paper itself). While definitely a potentially exciting development, skepticism is recommended.

Read more : Original Press Release
Read more : Critics
Read more (Technical): Scientific Article

“Sequencing” Proteins

It’s all well and good that industrious scientists are breaking Moore’s Law for DNA-sequencing, but what of the genetic end-products, proteins? Current methods for protein determination are expensive, limited in scope, often require purification and aren’t amenable to scaling. Researchers in the Church Lab at Harvard are changing that, starting with the area of protein-protein interaction. By specifically tagging proteins with DNA-barcodes, spreading and immobilizing the bulk sample, and then amplifying the DNA tags, researchers could then “sequence” co-localized proteins. Through statistical leveraging (i.e. taking 1 million samples per mm^2), researchers built protein interaction profiles for GPCRs1 and antibodies.

Read more (Technical) : Nature Article


  1. G protein-coupled receptors, a protein family of receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses