This week in science (#41)

Solvent-free Enzymes

The first completely water and solvent-free reactive enzyme system has been developed at University of Bristol. Industrial biosynthetic processes often use enzymes designed or evolved to tolerate increasing amounts of organic solvents, yet it has been a dogmatic tenet that water-protein interactions must be sufficiently maintained for sustained structure and function. By modifying the surface of fatty acid lipases (enzymes that break down fats), researchers were able to create a bioliquid entirely composed of these protein constructs. This will pave the way for more efficient and greener reaction processes that require less to none environmentally harmful solvents.

Read more : Authorea Coverage “Enzymes out of Water”
Read more (Technical): Nature Communications

Shockingly Bright Dead Star

Astronomers have found a pulsating, dead star beaming with the energy of about 10 million suns. This is the brightest pulsar – a dense stellar remnant left over from a supernova explosion – ever recorded. The discovery was made with NASA’s Nuclear Spectroscopic Telescope Array, or NuSTAR. The brightness comes from the energy released from material falling onto the compact. This is the result of the forceful gravitational pull exerted by the dead star. So far scientists believed that only black holes could devour their surroudings with such appetite. This is an exciting discovery, since it challenges physical models for the accretion of matter onto magnetized compact objects. These objects are believed to be responsible for some of the brightest explosions in the Universe.

Read more : NASA Press Release

Read more (Technical): Nature Article

Access to clinical data

In the EU starting January 1, 2015, all newly approved pharmaceuticals will need to have clinical trial data submitted to a public database. Identified researchers will have largely unfettered access to the data, while registered public users will be limited to on-screen viewing. This pharmacovigilence experiment’s desired outcome is to help inform the public as well as increase understanding among clinicians and the rate of advances of health care and biomedical researchers. Obviously, care must be taken to anonymize patient data and redact commercially-relevant information, but this will still be the broadest open-availability health initiative ever. FDA is considering similar requirements in the US. We’ll keep you posted.

Read more : ScienceInsider
Read more : Authorea Coverage “Clinical Trial Transparency”