There was no biochemical ADRs on liver, kidney, or glucose markers (See Figure 1). There were no statistically significant self-reported ADRs versus placebo (see Table 2). There were no major ADRs (e.g., hospitalization, new-onset disease, infection, or death). There was a significant 3.6% reduction in bicarbonate in the high-dose group versus placebo () with a similar trend in both low-dose groups. The combination of grape extract and low-dose pterostilbene decreased BUN by 7.1% from baseline (), but this reduction was not significant when compared to placebo (). There were no other significant effects on electrolyte markers.