To conclude, our model incorporates is based on tools from physcial chemistry and may be applied to diverse systems that rely on flexible linkers. Interaction networks of proteins that are part of signalling and regulatory networks are among the many examples in which multiple binding motifs are used to obtain integrative behavior. However, because of the abstract nature of the model, one may envision its use also beyond biology, in various systems where diffusion may be switched from free to constrained.
Acknowledgements
We thank Moshe White for his help in developing equation () and Appendix B. This research was supported by Grant no. 321993 from the Marie Skłodowska-Curie actions of the European Commission, and Grants no. 1417/13 and no. 1937/13 from the Israeli Science Foundation.
Supplemental Material
Appendix A - Detailed account of a system with a bivalent flexible linker