Robustness of iDEG to high percentages of DEG

The four methods were compared on RNA-Seq data with \(p\) as high as 40%. As shown in Panel B of Figure \ref{fig:sensitivity}, iDEG still performs better than edgeR even though the latter does not make the low-\(p\) assumption. Note, \(p=40\%\) is an unrealistic extreme case in biology since this would result in nearly half of the genes in the transcriptome being associated or altered by a disease.