Comparison of \(F_{1}\) scores for iDEG and other existing methods. Each point represents the average \(F_{1}\) scores resulted from 1000 repeated experiments, and the horizontal bars represent one standard deviation. Each panel presents one distributional assumption of RNA-Seq data (right: Study 1 = Poisson distribution, Study 2 = NB distribution with a constant dispersion parameter, Study 3 = NB distribution with a varying dispersion parameter as a function of expression mean). FDR \cite{benjamini-1995-controlling} cutoff is set to 0.1 for edgeR and DESeq; local fdr cutoff is set to 0.2 for iDEG. DESeq produced no results for the Poisson case and for some datasets in the other two panels. For visualization clarity, horizontal axes are set to different ranges.