Robustness of iDEG to high percentages of DEG
The four methods were compared on RNA-Seq data with \(p\) as high as 40%. As shown in
Panel B of Figure \ref{fig:sensitivity}, iDEG still performs better
than edgeR even though the latter does not make the low-\(p\)
assumption. Note, \(p=40\%\) is an unrealistic extreme case in
biology since this would result in nearly half of the genes in the
transcriptome being associated or altered by a disease.