Computational Algorithms

Sections \ref{sec:algorithm-Pois} and \ref{sec:algorithm-nb} describe the iDEG algorithms for Poisson and Negative Binomial distributed RNA-Seq data, respectively. In practice, investigators need to specify the distribution assumption according to their understanding of the data. The Negative Binomial distribution is more general, and its limiting case is the Poisson distribution when the dispersion parameter \(\delta_{g}\) goes to zero. We have developed an R package iDEG, available at https://github.com/QikeLi/iDEG.

iDEG Algorithm for Poisson RNA-Seq data described in Table \ref{alg}