Adaptive cutoffs were determined by iDEG. In terms of the \(log_{2}\) transformed fold change, iDEG, in general, sets cutoffs with larger values for lowly expressed genes and cutoffs with lower values for the highly expressed genes, which accounts for the precision of the gene expression measurement. Data are displayed in a typical MA plot. The x axis is the average of the \(log_{2}\) transformed expression counts, and the y axis is the \(log_{2}\) transformed fold change.