Cassava is an abundant and cheap source of starch. In this work, the hydrolysis of cassava starch using highly active solid catalyst,  Polyvinylpyridine (PVP)-chlorhydrate is compared with another acid solid catalyst, green clay activated with HCl, Amberlist 36, Montmorillonite KSF,  Zéolite, and silica was investigated. The reaction temperature and time are signifiant parameters for the catalytic hydrolysis of starch. In comparison to these investigations, PVP chlorhydrates appear to be an efficient, selective and recyclable catalyst for thermal starch hydrolysis. The highest glucose yields from cassava starch were observed 80% to 82% and 94% when including maltose and other sugars at 95°C during 22hours with PVP chlohydrate for various concentration of starch up to 600g/L. Glucose syrup obtained in this process could be compared to the commercial sources. Traces of HMF was the only one by-product and it could be separated by liquid-liquid extraction. Finally,  this cheap source of glucose and HMF as a by-product may be the starting materials for the conception of new bio-refinery. content goes here