Humantype I interferons belong to a large subgroup of interferons (IFNs) involved inregulating the activity of immune system [1] .All type I interferons bind to a specific cell surface receptor complex calledIFNAR thatconsists of IFNAR1and IFNAR2chains [2]in other words type I interferons including interferon-α and–β is stabilized by the IFNAR1 receptor [34]. IFNAR1 gene encodes theInterferon-alpha/beta receptor alpha chain protein [5].The IFNAR1 is crucial in activating JAK-STAT signaling pathway [6].Binding and activating the receptor stimulates Janus protein kinases; this inturn phosphorylate several proteins including STAT1 and STAT2 which results in the transcriptionalactivation of antiviral proteins such as MxA and 2’5’ oliogadenylate synthetize[7-9]