Multiplesclerosis (MS) isa long lasting degenerative often episodic disease of the central nervoussystem marked by patchy destruction of the myelin causedpresumably by an autoimmune process [10].More people are reportedly contracting MS [11];the increase has been witnessed in Iran’s population as well [12].A number of genetic variations are known to contribute to the risk of contractingMS. Some genes suspected to have been involved in MS initiation e.g. MMP-9[13] andTIMP-1 [14]have already been investigated in the Iranian population.  In addition we studied association of severalgene polymorphisms and expression involving in immune system with MS disease[15-19]. Nonetheless there are many more genes such as the IFNs stillwaiting to be investigated. To this end the current study aims to evaluate theexpression of IFNAR1gene in whole blood of relapsing-remitting MS(RR-MS) patients the most common form of MS compared to normal individuals.