Resultaten

Human type I interferons belong to a large subgroup of interferons (IFNs) involved in regulating the activity of immune system [1] . All type I interferons bind to a specific cell surface receptor complex called IFNAR  that consists of IFNAR1 and IFNAR2 chains [2] in other words, type I interferons including interferon-α and –β is stabilized by the IFNAR1 receptor [3, 4].  IFNAR1 gene encodes the Interferon-alpha/beta receptor alpha chain protein [5].
The IFNAR1 is crucial in activating JAK-STAT signaling pathway [6]. Binding and activating the receptor stimulates Janus protein kinases; this in turn phosphorylate several proteins, including STAT1 and STAT2, which results in the transcriptional activation of antiviral proteins such as MxA and 2’,5’ oliogadenylate synthetize [7-9]