Introduction
hshshs\cite{Youngstein_2017}
Scoping reviews aim to map the existing literature in a field of interest in terms of the volume, nature and characteristics of the primary research (cita). A scoping review can thereby identify research gaps for future studies. This review has been driven by an a priori protocol which aimed to provide a comprehensive, clinically useful summary of the available evidence on the indications for and the mechanisms of action, efficacies, and safety of IL-1 pathway-targeting drugs that are used to treat dermatological diseases\cite{G_mez_Garc_a_2018}. In this first summary we will present and discuss the results of that scoping review for the Cryopyrin-associated Periodic Syndrome (CAPS). Our main objectives are:
- Review the evidence for mapping the studies in the interleukin-1 treatment of CAPS.
- Review the evidence for study the epidemiology of interleukin-1 in the treatment of CAPS.
- Review the evidence of different CAP phenotypes treated with interleukin 1 inhibitors
- Review the evidence of the different genotypic variations of CAP treated with interleukin 1 inhibitors
- Review the evidence for the efficacy and safety of interleukin-1 in the treatment of CAPS.
- Obtain concrete research questions that can be answered by performing systematic reviews.
- Identify research gaps in the existing literature.