Materials and methods
A scoping review protocol to explore the use of interleukin-1-targeting drugs for the treatment of dermatological diseases was a priori published in 2018\citep{G_mez_Garc_a_2018a}. This work summarizes the findings found related with the CAPS sub-study.
Literature search
We performed a three-step literature search to identify and locate all relevant studies. The first step was performed on 9th March 2018 and entailed a limited search strategy [SEARCH QUERY('skin disease' AND (('interleukin 1beta'/exp OR 'interleukin 1beta') OR 'interleukin 1')) AND 'therapy'] in the MEDLINE and EMBASE databases. After that, we extracted keywords from titles, abstracts, and indexing categorizations and used them to perform a new search on 10th March 2018 with a more complex strategy (Table S1 on Suplemmentary Information). Results were ordered by diseases reviewing the title and abstract. After screening by title and abstract, XXX sources related to CAPS were selected for this work. The third step involved a new search using the reference lists of all the identified reports and articles for additional studies. Finally, XX sources were included for complete analysis. The literature search and title and abstract filtering were carried out independently by two researchers (FG-G and JLS-C). Figure 1 displays the PRISMA chart showing the flow of studies from study identification to data extraction.
Data charting