Acknowledgements
Work funded by UIDB/04046/2020 and UIDP/04046/2020 centre grants (to BioISI) from FCT, Portugal and research grant ERARE15-pp-010/JTC 2015 INSTINCT from FCT, Portugal (to MDA) and from CF Canada, FRQS and CIHR (to JWH and DYT). The authors thank Sofia Correia and Luís Marques (both from BioISI) for technical support and Cystic Fibrosis Foundation Therapeutics (CFFT, USA) for C18 compound and 596 anti-CFTR antibody.