A comment on the value of screening1

  1. This blog post was originally published 14th February 2014 at http://aheblog.com/2014/02/14/a-comment-on-the-value-of-screening

Everybody’s talking about screening again, with good reason. Research seems to suggest that screening for breast cancer, using mammography, is not effective (let alone cost-effective)(Miller 2014). Here I present a view on the value of screening; the validity of which I am yet to fully convince myself.

Why screening?

The point of screening is the early detection of disease, or the identification of increased risk of disease, in people without symptoms. It is based on the idea that commencing treatment or care at an earlier stage of disease can be beneficial to an individual’s health or well-being in the long-term, including life-extension. Read that sentence again – it’s important. So, the potential value of screening is commensurable to the incremental value of early treatment or care over and above treatment or care that begins with the onset of symptoms. However, as I suggest below, a screening trial is not the best way to capture this.

The value of treatment for disease is clear. Treatment can directly improve health and well-being, and this is something to which people attach value. The same cannot be said of screening, which in and of itself is not health-improving. I believe that we need to stop valuing screening in terms of its ability to extend life and quality of life. It may serve to give people peace of mind, but this is not something that we routinely consider in the evaluation of screening. The true value of screening lies in the extent to which it provides us with new knowledge about a patient; a screening intervention with better sensitivity and specificity is of greater value. It seems perverse to suppose that an intervention that provides us with information can be ‘ineffective’ in terms of health outcomes, or even harmful. The error is surely in our use of that information.

The redundancy of screening trials

To capture the value of screening we do the same as for any other health care intervention; we carry out an RCT. It appears to me that screening trials are unnecessary, of little value and potentially dangerous. This may be a foolhardy suggestion given that my employment depends upon a screening trial, but I’ll go on.

I’ll tackle my three claims in reverse order. Firstly, screening trials are potentially dangerous. This is simply because screening is potentially dangerous. As we’ve already established, the value of screening is derived from the value of treatment for the disease for which an individual is being screened. If a person is screened positive, they may be able to receive treatment earlier than they otherwise would. However, it seems unlikely to me that the treatment they will receive has been evaluated in asymptomatic individuals like themselves. Trials of pharmaceuticals, surgery or other health care interventions are invariably carried out in populations with symptomatic disease. Therefore, our understanding of the benefits, costs and side-effects of the treatment may not be relevant to individuals receiving treatment after being screened positive. The e