Assessment
Four tools that ranked highly in CAFA-2 will be compared in the scope of this evaluation: ARGOT2, EVEX, INGA and SIFTER. In order to standardized analysis of these tools, results will be compared to BLAST. An average researcher would likely use BLAST and trust the output, so utilizing the BLAST search as the baseline for comparison is a logical workflow. Researchers are familiar with this tool and have a good understanding of how to use it, what the output means and how to input protein sequences. These factors will be taken into account when looking at the CAFA-2 tools.