ARGOT2

ARGOT2, Annotation Retrieval of Genel Ontology Terms, \cite{Falda_2012} is a protein function predictor that uses a combined approach, much like INGA. Falda et al. recognize that any single approach can introduce inaccuracies and have various reliability issues. ARGOT2 is an attempt to improve this by retrieving GO annotations from both a BLAST search and a HMMR \cite{Durbin} search against the Pfam database. Once the GO annotations are retrieved, it utilizes a "clustering process of GO terms dependent on their semantic similarities and a weighting scheme which assesses retrieved hits sharing a certain degree of biological features with the sequence to annotate." \cite{terms} ARGOT2 scored in the top ten for molecular function and biological process in the CAFA2 challenge.