The network structure of depressive symptoms in adolescence: what happens during treatment?


[problem: heterogeneity, no prognostic value, responder non-resonder, we're working with a classificationsystem that doesn't work.]
[biology: network models are everywhere, explain fundamentals of everything, in psychiatry now too, can we use it?]

Research question: can we use the network of depressive symptoms as a meaningful phenotype? 1. Can we reliably estimate network strength independent of actual symptom levels. 2. Does network strength differentiate between:
-        Acutely depressed versus matched never-depressed adolescents
-        For responders, acutely ill state versus recovered state
-        At baseline, future responders versus future non-responders
3. Is network strength associated with other (non-depression) outcomes?



Adolescents with depression were sampled from the IMPAC