Patient information
This investigation was approved by the Colorado Multiple Institution Review Board (COMIRB). All medical imaging analyses were conducted on de-identified data collected during the standard-of-care procedures for routine STN-DBS implantation surgery in patients with idiopathic PD, using a retrospective chart-review IRB-approved protocol. Patient information was organized with respect to sex ratio, age distribution, and length of stimulation.
a. Total patients: 30 PD patients, and 3 ET patients.
b. Male to Female ratio: 19:14.
c. Age range: 46-80 with a mean of 63.30 (± SD 7.76)
d. Length of stimulation in days: short = 0-55; medium = 55-306; long = >306.
Following approval by Colorado Multi Institutional Review Board (COMIRB), 30 subjects with idiopathic PD and 3 subjects with ET were recruited for the study. All subjects demonstrated typical parkinsonian motor symptoms, including tremor, akinesia, and rigidity or classic ET with upper limb kinetic tremors. PD inclusion criteria for the study included the diagnosis of idiopathic PD and a positive response to anti-Parkinson medication, amounting to a greater than 30% improvement on the motor subscale of the Unified Parkinson’s Disease Rating Scale (mUPDRS) in the on- vs off-state, a brain MRI scan lacking significant abnormalities, and medical clearance for surgery. All study subjects provided written consent for participation. Patients over the age of 75 or under the age of 18, those at increased risk of infection (e.g., comorbid diabetes or history of recurrent infections), and patients with significant cognitive deficits or untreated psychiatric disorders (e.g., depression) detected on neuropsychological testing were excluded from this study.