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  • A reconstruction of the phase dynamics of interacting cell cycle and circadian clock
    Going Full Circle: reconstructing the phase dynamics of interacting cell and circadian cycles.

    Closing the loop: a reconstruction of the phase dynamics of interacting cell cycle and circadian clock

    A cell portait: reconstructing the dynamics of two coupled oscillators



    “Coupled oscillators are not only of great biological importance, but also very interesting from a dynamical systems point of view. In a systems biology context, the interconnection between two periodic processes such the circadian rhythm and the cell cycle represents an ideal analyzable system at the single-cell level. The analysis of a large dataset from time-lapse imaging of single mouse fibroblast showed, in our previous study, that circadian and cell cycle are robustly synchronized. This synchronization state is observed over a wide range of conditions resulting from a predominant influence of the cell cycle on the circadian cycle. Moreover, parameters of the coupling functions has been identified with stochastic modeling of two interacting phase oscillators. Here, we reconstruct a non-parametric model of the phase dynamics, identifying new potential interactions between the two processes. This allows us to make more specific predictions on precise cell cycle events that could influence the circadian clock, such the condensation of chromosomes coinciding with transcriptional shutdown, and subsequently testing those prediction using different markers of cell cycle events. By analyzing several conditions we found that the phase relationship of the two systems presents shifts characteristic of resonating oscillators. In conclusion, we highlight how the use of a statistical model allows the understanding of the interaction between two important cellular processes by reducing the complex dynamics to a low dimensional phase model. ”

    Author Summary

    150–200 word non-technical summary written in the first-person voice, Aim to highlight where your work fits within a broader context; present the significance or possible implications of your work simply and objectively; and avoid the use of acronyms and complex terminology wherever possible. “-Impact of cell cycle perturbation on circadian clock/ Understanding the properties of the circadian clock - Low dimensionality”



    The circadian clock and the cell cycle oscillators represent two cellular processes having a period in the range of one day. At the single-cell level, the circadian r