A reconstruction of the phase dynamics of interacting cell cycle and circadian clock
Going Full Circle: reconstructing the phase dynamics of interacting cell and circadian cycles.

Closing the loop: a reconstruction of the phase dynamics of interacting cell cycle and circadian clock

A cell portait: reconstructing the dynamics of two coupled oscillators

Abstract

Abstract

“Coupled oscillators are not only of great biological importance, but also very interesting from a dynamical systems point of view. In a systems biology context, the interconnection between two periodic processes such the circadian rhythm and the cell cycle represents an ideal analyzable system at the single-cell level. The analysis of a large dataset from time-lapse imaging of single mouse fibroblast showed, in our previous study, that circadian and cell cycle are robustly synchronized. This synchronization state is observed over a wide range of conditions resulting from a predominant influence of the cell cycle on the circadian cycle. Moreover, parameters of the coupling functions has been identified with stochastic modeling of two interacting phase oscillators. Here, we reconstruct a non-param