Human Organs-On-Chip are microfluidic devices with micrometer-sized channels lined by living human cells that provide physiologically relevant geometry and mechanical forces to mimic organ-level functions (5). The laboratory of my mentor, Dr. Donald Ingber, pioneered this technology highlighted by the human lung-on-a-chip where the alveolar-capillary interface and gas exchange were modeled under cyclic breathing like motion (6). Human organs-on-chip not only test the role of mechanical forces and 3D organization, they perform physiological functions and model disease phenotypes more faithfully. For example, the lung-on-a-chip revealed a novel requirement for endothelial cells in IL-2 induced pulmonary edema, seen in melanoma patients treated with IL-2, and resulted in the discovery of a novel therapeutic that suppresses this toxicity (7).