This section, compiled by the principal applicant in consultation with the other applicants, should integrate the different research strategies of the collaborators into a single, combined research plan. It should contain the following elements: i) scientific background of the proposal  ii) outline of the objectives and integrated research plan, and allocation of the research to each applicant iii) the necessity for international collaboration. This should include an explicit statement of which collaborative elements are essential for the project and how the collaboration will work (if more detail is required than was possible within the limits of the Overview - item 5 above) iv) detailed description of the research project of each collaborating team member v) note that preliminary data are not necessary vi) in the case of applications with theoretical components (eg mathematical modelling, bioinformatics), the theoretical approaches and their interaction with experimental strategies should be clearly described. The committee includes members with appropriate expertise vii) A discussion of potential problems and alternate strategies if these are encountered.