The paper discusses the synthesis and a stereo chemical aspect of the novel selective androgen receptor modulator scaffold has been discovered through structural modifications of hydantoin antiandrogens to 4-((3aS,6aR)-2-oxohexahydro-1H-furo[3,4-d]imidazol-1-yl)-2-(trifluoromethyl)benzonitrile analogs were evaluated in human androgen receptor binding and cellular functional assays.