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Window anastomosis technique for repair of supracardiac total anomalous pulmonary ven...
Gang Wang
Gengxu Zhou

Gang Wang

and 4 more

July 21, 2022
Outcomes of operations for total anomalous pulmonary venous connection (TAPVC) have improved.However, postoperative pulmonary venous obstruction (PVO) remains the most significant complication, with high morbidity and mortality. We introduce a window anastomosis technique for repair of supracardiac TAPVC in infants. The mainstay of the surgical technique is to resect the anterior wall of the pulmonary vein confluence(PVC) and part of the posterior wall of the left atrium to form a large and undistorted “window to window” anastomosis.
BRAF Mutation in Neuroblastoma: A Case Report of a Rare Finding
Sara Hutchins
Sara Ferguson R

Sara Hutchins

and 4 more

July 21, 2022
Neuroblastoma is the most common extracranial solid tumor in children. Approximately half of the patients with Stage MS disease have tumor regression, but 10-15% will have progression of disease. BRAF mutations are common in some cancers, such as melanoma and pediatric astrocytoma, but are rare in pediatric extracranial solid tumors, including neuroblastoma. Here we report the case of an infant with Stage MS neuroblastoma with a rare BRAF V600E mutation and subsequent progression to Stage M disease.
Tranexamic acid-associated fatal status epilepticus in a paediatric patient
Dr Santosh Patel

Dr Santosh Patel

July 21, 2022
Title:Tranexamic acid-associated fatal status epilepticus in a paediatric patientAuthor:Dr Santosh Patel MD, FRCA, PG Dip (Med Edu)Consultant AnaesthetistDepartment of anaesthesiaTawam hospitalAl AinUnited Arab EmiratesCorrespondence address: as above.Email: skpatel@seha.aeFunding: No source of funding to declareConflicts of interest: Nothing to declareDear Editor,I have read with interest a case report and literature review published in the British journal of pharmacology on tranexamic acid (TXA) associated SE in a 4-year child who underwent tonsillectomy.1 I would like to congratulate the authors for reporting the case despite the fatal outcome. Considering that the use of TXA is expanding to minimise blood loss in a wide range of surgeries, an evidence-based therapeutic approach for its associated seizures is of paramount importance.The authors described in their report (also mentioned in Table 2) and concluded that general anaesthetics, propofol and halogenated inhaled anaesthetics are considered the first line of management of TXA-associated seizures due to their direct activity at glycine receptors. In support of their statement, they have quoted three references (references 35,45,46 in their report). However, in their articles, the authors did not recommend the use of general anaesthetics (propofol and halogenated inhalational anaesthetics) as the first line of treatment for TXA-related seizures. It is valuable to point out to the readers that their conclusion is not valid and needs clarification and correction.TXA-associated hyperexcitability of neural networks is because it is a competitive antagonist of glycine and GABAA receptors.2 Following IV TXA administration, not all seizures progress to status epilepticus. Although TXA-related seizures commonly manifest as generalised tonic-clonic activity, focal seizures have been reported; which are not an indication for the use of general anaesthetics. Refractory status epileptics (RSE) and super RSE are uncommon following IV TXA although this is a common feature following intrathecal TXA.3Propofol’s anticonvulsant, hypnotic, sedative and anaesthetic effects are mediated via multiple complex molecular mechanisms, including modulation of GABAA and glycine receptors. GABAA receptor modulation by propofol has distinct dose-dependent effects likely involving multiple sites of action; clinical concentrations of propofol potentiate GABA-activated currents, increase open channel frequency, and reduce the rate of desensitization, while intermediate concentrations directly activate GABAA channels, and even higher concentrations inhibit receptor function.4Propofol can cause neuroexcitatory effects, including tonic-clonic seizures, particularly during the start or weaning from propofol infusion.5 Among the various mechanisms that have been proposed for these neuroexcitatory symptoms are antagonism of glycine and dopamine receptors, hyposensitization of GABAergic pathways and dysregulated inhibition of NMDA glutamate receptors.6Its use is associated with side effects, including hypotension (and the associated use of vasopressors) and respiratory depression. With prolonged infusion, propofol infusion syndrome (PIS) may occur, which may contribute to morbidity and mortality of RSE. Children are more susceptible to developing this complication. Propofol infusion therapy is not recommended as the first line of treatment for TXA-associated seizures, and its use is reserved for severe cases in children.Inhalational anaesthetics are beneficial for the control of seizure activity via inhibition of NMDA excitotoxicity and potentiation of inhibitory functions of GABAA and glycine receptors. However, it is essential to highlight that there are several limitations to the use of inhalational anaesthetic agents. First, the only clinical evidence of their use is from the minimal number of case reports. Second, TXA-related seizures often manifest in the postoperative period in the recovery room or in ICU, where delivery and scavenging of inhalational agents via ventilator may not be feasible. Third effective end-tidal concentration and optimal therapeutic duration are not known. Finally, in higher concentrations, they cause cardiac depression and cerebral vasodilation. Therefore, their use is limited as salvage therapy for the management of TXA-associated RSE and super RSE.In summary, the authors’ conclusion is incorrect, and clinicians should follow currently available evidence-based professional guidelines to manage TXA-associated status epilepticus.8,9References:1. Aboul-Fotouh S, Habib MZ, Magdy SM, Hassan BEE. Tranexamic acid-associated fatal status epilepticus in a paediatric non-cardiac surgery: A case report and literature review. Bri J Clin Pharmacol 2022;1-6. doi:10.1111/bcp.152962. Lecker I, Wang D, Whissell P, et al. Tranexamic acid-associated seizures: causes and treatment. Ann of Neurol 2015;79(1):18-26. doi:10.1002/ana.245583. Patel S, Robertson B, McConachie I. (2019). Catastrophic drug errors involving tranexamic acid administered during spinal anaesthesia.Anaesthesia ,74(7),904-14 https://doi.org/10.1111/anae.146624. Platholi J, Hemmings H. (2022). Effects of general anesthetica on synaptic transmission and spasticity. Currt Neuropharmacol2022;20(1):27-54. doi: 10.2174/1570159X19666210803105232.5. Walder B, Tramèr MR, Seeck M. (2002). Seizure-like phenomena and propofol: a systematic review. Neurology 2002; 58(9):1327-32. 10.1212/wnl.58.9.13276. Pantelakis L, Alvarez V, Gex G, Godio M. Severe neuroexcitatory reaction: A rare and underrecognized life-threatening complication of propofol-induced anesthesia. The Neurohospitalist2021;11(1):49-53. doi: 10.1177/1941874420929536.7. Godec S, Gradisek MJ, Mirkovic T etal. Ventriculolumbar perfusion and inhalational anesthesia with sevoflurane in an accidental intrathecal injection of tranexamic acid: unreported treatment options. Reg Anesthe Pain Med 2022;47(1):65-68 10.1136/rapm-2021-1024988. Nelson SE, Varelas PN. Status epilepticus, refractory status epilepticus, and super-refractory status epilepticus. Continuum (Minneap Minn). 2018;24(6):1683-1707.9. Vossler DG, Bainbridge JL, Boggs JG etal.. Treatment of refractory convulsive status epilepticus: a comprehensive review by the American Epilepsy Society Treatments Committee. Epilepsy Curr.2020;20(5):245-64.
Rumpel-Leede Phenomenon as a Rare Complication After Transulnar Percutaneous Coronary...
Letícia Sandoval
Nayara Cafundó

Letícia Sandoval

and 4 more

July 21, 2022
The Rumpel-Leede phenomenon is when the distal dermal capillaries of an extremity rupture in response to local mechanical pressure, such as an inflated blood pressure cuff or a compression band, disrupting the capillary membrane. This article presents an image of the rumpel-leede phenomenon after transulnar percutaneous coronary intervention.
Safety of day-case endoscopic sinus surgery in England: An observational study using...
Annakan Navaratnam
Alfonso Pendolino

Annakan Navaratnam

and 9 more

July 21, 2022
Background: As elective surgical services recover from the COVID-19 pandemic a movement towards day-case surgery may reduce waiting lists. However, evidence is needed to show that day-case surgery is safe for many ENT operations including endoscopic sinus surgery (ESS). We aimed to investigate the safety of ESS in England. Methods: This was an observational, secondary analysis of administrative data. Participants were all patients in England undergoing elective ESS procedure aged ≥ 17 years during for the five years from 1st April 2014 to 31st March 2019. The exposure variable was day-case or overnight stay. The primary outcome was emergency readmission within 30 days post-discharge. Results: Data were available for 49,223 patients operated on across 129 NHS hospital trusts. In trusts operating on more than 50 patients in the study period, rates of day-case surgery varied from 100% to 20.6%. Rates of day-case surgery increased from 64.0% in 2014/15 to 78.7% in 2018/19. Day-case patients had lower rates of 30-day emergency readmission (odds ratio 0.71, 95% confidence interval 0.62 to 0.81). For secondary outcomes measures, there was no evidence of poorer outcomes for day-case patients. Outcomes for patients operated on in trusts with ≥80% day-case rates compared to patients operated on in trusts with <50% rates of day-case surgery were similar. Conclusions: ESS can safely be performed as day-case surgery at current rates. There is a potential to increase rates of day-case ESS in England, especially in departments that currently have low rates of day-case ESS.
Extra Perichondrium Patch to Enhance Cartilage Graft during Endoscopic Cartilage Myri...
Bing Wang
Jin Zhang

Bing Wang

and 5 more

July 21, 2022
Abstract Objectives The aim of this study was to evaluate whether adding an extra perichondrium patch to enhance the cartilage graft during endoscopic myringoplasty can improve the healing rate and post-operative hearing of patients with poor prognostic factors (eustachian tube dysfunction, large perforations, subtotal perforations and marginal perforations). Methods This retrospective study analyzed a total of 80 patients (40 females and 40 males, median age of 40.55 years) who had received an extra patch during endoscopic cartilage myringoplasty. Patients were followed up for six months. Healing rates, complications, preoperative and postoperative pure-tone average (PTA) and air-bone gap (ABG) were analyzed. Results At six months follow-up, the healing rate of tympanic membrane was 100% (80/80). The mean preoperative pure-tone average (PTA)(43.18± 14.57 dB HL)significantly decreased (27.08±9.36 dB HL) six months after the operation (P=0.002). Similarly, the mean preoperative ABG(19.05±5.72 dB HL)reduced to(9.36±3.75 dB HL) (P=0.0019) at sixth month. Major complications were not observed during follow-up. Conclusions The usage of an extra patch during endoscopic cartilage myringoplasty for large, subtotal and marginal tympanic membrane perforations achieved a high healing rate and a statistically significant hearing gain with low incidence of complications.
Coexistence of schizencephaly and intracranial developmental venous anomaly in a midd...
Mahsa Masjedi Esfahani
Seyed Mohammad Ali  Mirazimi

Mahsa Masjedi Esfahani

and 3 more

July 21, 2022
Schizencephaly is a rare developmental disorder of the central nervous system (CNS) marked by abnormal clefts or slits spreading from the lateral ventricle to the cerebral hemispheres.Developmental venous anomaly (DVA) is a benign venous anomaly draining cerebral parenchyma. DVAs are usually asymptomatic and do not cause any complications.
Recent Trends toward Privacy-preservation in IoT, its Challenges and Future Direction...
Mahdi Safaei Yaraziz
Ahmad Jalili

Mahdi Safaei Yaraziz

and 3 more

July 21, 2022
The Internet of Things (IoT) is a self-configuring, intelligent system in which things connect to the Internet and communicate with each other. As “things” are autonomous and rely on a significant amount of autonomy to carry out their individual and collective tasks, it is possible that the autonomous environment of IoT may raise privacy concerns. IoT encounters significant privacy and security challenges, including inaccurate device updates, a lack of efficient privacy solutions, user unawareness, and famed active device monitoring capabilities. In this paper, the authors describe the background of IoT systems and privacy and security measures, (a) approaches to preserving privacy in IoT-based systems, (b) existing privacy solutions, and (c) recommending privacy models for different layers of IoT applications. Based on the results of our study, it is clear that new methods such as Blockchain, Machine Learning, Data Minimization, and Data Encryption can greatly impact privacy issues to ensure security and privacy. Moreover, it makes sense that users can protect their personal information easier if there is less data to collect, store, and share by smart devices. Thus, the use of Data Minimization methods in these networks can be very beneficial for privacy-preserving, which is useful to route researchers to
Design and Spectral Validation of RAD51 Inhibitors Based on BRC4 (1523-1546)
Boyuan Pan
Linna Fu

Boyuan Pan

and 5 more

July 21, 2022
RAD51 is a core factor for homologous recombination (HR) to repair DNA double strand breaks and overexpressed in breast cancer cells. Truncated peptide BRC4 (1523-1537) was obtained by computer simulation which had the highest binding free energy targeting RAD51. To enhance the binding affinity to the target protein, six nicotinic acid derivatives were modified at the N-terminal of BRC4 (1523-1537) by Fmoc solid-state synthesis to obtain nicotinamide-modified peptides. The interaction of RAD51 (181-200) with BRC4 (1523-1537) and nicotinamide-modified peptides were verified by circular dichroism (CD) spectroscopy and fluorescence spectroscopy. In conclusion, modifying small molecule pharmacophores can improve binding ability. According to spectral results, 2-chloro-5-fluoronicotinic acid modified BRC4 (1523-1537) has the most significant influence on the secondary structure of RAD51 (181-200); binding constant is 1.1×10 4 L·mol -1. Cell experiments showed that BRC4 (1523-1537) modified with nicotinic acid N-oxide had the best inhibitory effect on the proliferation of MDA-MB-231 cells.
Recurrences of tachycardia after repeated slow pathway ablation: What is the diagnosi...
Soorampally Vijay
Harshad Shah

Soorampally Vijay

and 2 more

July 21, 2022
A 30-year-old man with a structurally normal heart was referred to us with a 2-year history of recurrent episodes of rapid paroxysmal palpitations. A few episodes required hospitalization and were terminated with intravenous diltiazem. During electrophysiology (EP) study done twice before in other hospitals, the patient was diagnosed as typical atrioventricular nodal reentrant tachycardia (AVNRT) and underwent radiofrequency ablation of the slow pathway. However, the episodes recurred.  Because of the patient’s persistent symptoms, an EP study was performed again. Tachycardia was easily induced using atrial extrastimuli, ventricular extrastimuli and with rapid atrial pacing.
Ventricular Tachycardia Ablation in Arrhythmogenic Cardiomyopathy: A case report
Angel Cueva-Parra
Jorge Gómez-Flores

Angel Cueva-Parra

and 6 more

July 21, 2022
Arrhythmogenic cardiopathy is a genetic disease that mainly affects young men and mainly involves the right ventricle. It is responsible for up to 25% of sudden deaths in children under 35 years of age [1]. To make its diagnosis, certain criteria are required, such as the characteristic electrocardiographic alterations in sinus rhythm, the presence of documented ventricular tachycardia and structural abnormalities especially in the right ventricle [2]. We present the case of a 25-year-old male patient with a confirmed diagnosis of arrhythmogenic cardiopathy who underwent ablation with a ventricular tachycardia catheter with an endocardial -epicardial approach.
Left Bundle Pacing in a Patient with Atrio-Ventricular Canal Defect Presenting with A...
Kostantinos Aronis
Eunice Yang

Kostantinos Aronis

and 5 more

July 21, 2022
A 37-year-old woman with a history of incomplete atrioventricular canal and an extensive history of corrective cardiac surgeries presented with recurrent episodes of acute decompensated heart failure in the presence of junctional bradycardia with chronotropic incompetence. The initial plan was to proceed with implantation of a dual chamber pacemaker but given high index of suspicion for the presence of atrial standstill in the context of her extensive cardiac surgical history, we performed electroanatomical mapping and echocardiography at the time of pacemaker implantation that confirmed atrial standstill. Islands of electrically functional atrial myocardium were detected. Pacing from these locations resulted in local atrial capture, but failed to result in global atrial electrical capture, mechanical atrial contraction, or atrioventricular conduction. In light of the dismal outcomes of right ventricular pacing in patients with atrial standstill, we implanted a left bundle branch pacing lead that resulted in improvement of patient's cardiac output and prevented future admissions for decompensated heart failure in one year follow up.
Evaluating the direct and indirect effect of climate and human activities on long-ter...
tiantian chen
Yuxi Wang

tiantian chen

and 3 more

July 21, 2022
Understanding the long-term characteristics of vegetation variations and their relationship to climate and human activities is important for regional sustainable development and ecological construction. Herein, the normalized difference vegetation index (NDVI) was selected as a proxy, related method and algorithm were applied to obtain the nonlinear characteristics of long-term interannual NDVI in China. Partial least squares-structural equation modeling was employed to separate the effects of climate and human activities on vegetation greening. Further, geographically weighted regression was applied to explore the spatial correlations among comprehensive forces and vegetation growth and achieve the partitioning of driving forces. The results suggested that vegetation growth in China experienced an abrupt change in 1995, there was obvious vegetation browning during 1990–1995, and noticeable vegetation recovery from 1996 to 2018. Climate was a directly main driving force for vegetation increasing in China. The positive effect of climate was the most obvious in south China, with a path coefficient of 0.348. However, climate was significantly negative to vegetation growth in northwest China (-0.049). Improving socio-economic conditions had a slightly negative impact on vegetation greening, while ecological policy played a direct and obvious role in promoting vegetation growth, especially in northwest China, with a path coefficient of 0.295. Furthermore, ecological policy would directly affect the microclimate in northwest China, strengthen the restraint effect of water resources on vegetation, and then indirectly hinder vegetation increasing. Therefore, the implementation of ecological policies should be adjusted according to regional climatic conditions, to avoid the traditional way of increasing forest (grassland) area, and reduce the contradiction between water, soil and vegetation. Actually, the indirect effect of socio-economic conditions and ecological policy on vegetation growth was far greater than its direct impact in some cases; therefore, research attention should be paid to the indirect effects of driving forces on vegetation growth
Feather characteristics for eye protection in an insectivorous passerine: the Iberian...
Frédéric  Labouyrie

Frédéric Labouyrie

July 21, 2022
In the French Mediterranean plain, the northern extreme of its native range, the Iberian grey shrike, Lanius meridionalis, predominantly feeds on arthropods. Its type of loral plumage plays a key role in protecting its eyes while transporting large prey. The aims is to understand the role played by feathers in protecting the animal from various types of defensive prey. We combine an inspection of large insect prey types found on larders with a review of bird specimens found in museum collections to examine the morphometric characteristics of rictal feathers and culmen. In addition, precision photographs are used to observe the posture of the plumage in natura. We could identify four categories of protective feathers: clustered bristles, semi-bristles, semi-plumes distributed in the loral area, and semi-plumes above the eyes. Our results suggest that the Iberian grey shrike has a complex structure of loral feathers, specific to its foraging activity and prey types. In France, local species have longer beaks than their Spanish counterparts which suggests a more insect-based diet.
CT-imaging vs. high-density mapping in ischemic cardiomyopathy VT ablation: in whom d...
Thomas Fink
Vanessa Sciacca

Thomas Fink

and 2 more

July 21, 2022
CT-imaging vs. high-density mapping in ischemic cardiomyopathy VT ablation: in whom do we trust?Thomas Fink, MD1, Vanessa Sciacca, MD1, Philipp Sommer, MD11Clinic for Electrophysiology, Herz- und Diabeteszentrum NRW, Ruhr-Universität Bochum, Bad Oeynhausen, Germany.Disclosures: PS is advisory board member of Abbott, Biosense Webster, Boston Scientific and Medtronic.Funding: (None)
Evaluation of flavonoids and catechins of Venezuelan cocoa: spectroscopic characteriz...
Ruth Monroy
Ingrid Velasquez

aaa

and 5 more

July 20, 2022
A document by Ruth Monroy. Click on the document to view its contents.
A bioenergetic framework for aboveground terrestrial food webs

Fernanda S Valdovinos

and 9 more

October 17, 2022
A document by Sophia Simon. Click on the document to view its contents.
The impact of socioeconomic factors on vegetation restoration in karst regions: a per...
Ershuang Yuan
Qiuwen Zhou

Ershuang Yuan

and 6 more

July 20, 2022
Socioeconomic factors are important parameters that affect vegetation changes in karst areas. Previous studies primarily focused on ecological engineering when analyzing the impact of human activities on vegetation restoration, whereas the impact of socioeconomic factors has been less studied. Using the methods of structural equation modeling and geographically weighted regression, this study quantitatively analyzed the interactive effects of socioeconomic factors on vegetation changes in karst areas using counties as the research unit. The results showed that both the enhanced vegetation index and net primary productivity in the humid karst areas of China showed an increasing trend between 2000 and 2020. Among the socioeconomic factors, non-agricultural economy and rural economy had a positive effect on vegetation change, with maximum path coefficients of the structural equation model of 0.79 and 0.64, respectively; whereas population pressure had a negative impact with a minimum path coefficient of –0.80. Over time, the positive impact of rural economy on vegetation restoration showed an increasing trend, and the path coefficient increased from –0.92 to 0.64; in turn, non-agricultural economy and population pressure showed a decreasing trend. Moreover, because they were affected by the heterogeneity of the karst mountain environment, the impact of various socioeconomic factors on vegetation restoration had obvious spatial non-stationarity. The results of this study will promote our understanding of the mechanism underlying vegetation change in humid karst areas and provide scientific reference for ensuring the sustainability of the ecological effects in these areas.
Successful mapping and ablation of a pediatric-onset non-reentrant fascicular tachyca...
Yusaku Nagatomo
Susumu Takase

Yusaku Nagatomo

and 6 more

July 20, 2022
Non-reentrant fascicular tachycardia (NRFT) developed in a 6-year-old Japanese boy. Because of the drug-resistant recurrences, he received catheter mapping and ablation at age 10 years. An electrocardiogram exhibited a superior left axis deviation, a right bundle branch block-type configuration, and relatively narrow QRS with sharp R wave. It suggested verapamil-sensitive ventricular tachycardia (VT), but showed no sensitivity to verapamil or reentrant characteristics in the electrophysiological study. Detailed VT mapping determined the earliest presystolic Purkinje potential on the left posterior fascicle at the mid-ventricular septum. Radiofrequency current applications to the lesion led to his NRFT-free life without restriction for 16 months.
Flow visualization simulation of cemented tailings backfill slurry by particle tracki...
Haikuan Sun
Deqing Gan

Haikuan Sun

and 3 more

July 20, 2022
Pipeline flow visualization of cemented tailings backfill slurry (CTBS) improves the safety and stability of transportation. High turbidity and low resolution make it difficult for conventional methods to monitor the particle distribution state of CTBS in a short period of time. Particle tracking technology (PTT) is used to simulate and investigate the flow characteristics of CTBS pipeline, combine with theoretical analysis to construct a CTBS pipeline visualization model, elaborate the particle distribution state when CTBS flows in the pipeline, and explore the effects of pipe diameter (PD), flow velocity (FV) and tailings gradation (TG) on the particle distribution. The results show that particle tracking technology is better applied to investigate the particle transport distribution characteristics of CTBS tailings. Three concepts of particle accumulated gravity Ga, static friction angle θ and diameter dividing line are defined, and the transport pipe is divided into light wear zone, medium wear zone and heavy wear zone. The increase in pipe diameter increases the content of fine particles at the pipe wall and the thickness of the lubrication layer becomes larger, which improves the safety and stability of CTBS transport. The increased flow velocity reduces the settling phenomenon of large size particles and improves the transport efficiency, which increases the pipeline transport resistance. The wider the range of tailings gradation and the smaller the ratio of the number of large size tailings to small size tailings, the more suitable the tailings are for pipeline transportation as a backfill aggregate.
A genome for Cissus illustrates features underlying the evolutionary success in dry s...
Haiping Xin
Yi Wang

Haiping Xin

and 24 more

July 20, 2022
Cissus is the largest genus in Vitaceae and is mainly distributed in the tropics and subtropics. Crassulacean acid metabolism (CAM), a photosynthetic adaptation for the occurrence of succulent leaves or stems, indicates that convergent evolution occurred in response to drought stress during species radiation. Here, we provided the chromosomal level assembly of Cissus rotundifolia (an endemic species in Eastern Africa) and genome-wide comparison with grape to understand genome divergence within an ancient eudicot family. Extensive transcriptome data were produced to illustrate the genetics underpinning C. rotundifolia’s ecological adaption to seasonal aridity. The modern karyotype and smaller genome of C. rotundifolia (n = 12, 350.69 Mb/1C), which lack further whole-genome duplication, were mainly derived from gross chromosomal rearrangement such as fusions and segmental duplications, whilst sculpted by a very recent burst of retrotransposons activity. Bias on local gene amplification contributed to its remarkable functional divergence with grape and the specific proliferated genes associated with abiotic and biotic responses (e.g., HSP-20, NBS-LRR) enabled C. rotundifolia to survive in a hostile environment. Re-organization of existing enzymes of CAM characterized as diurnal expression patterns of relevant genes further confer to its present thriver in dry savannas.
A retrospective multicenter study of the prognostic impacts of platelet augmentation...
Jun Zhang
Liling Han

Jun Zhang

and 5 more

July 20, 2022
Background: Hepatoblastoma (HB) combined with secondary thrombocytosis is a common clinical condition. There is still no consensus on the need for antiplatelet therapy in patients with both HB and secondary thrombocytosis. Methods: We conducted a retrospective study of 229 children with HB who visited and were followed up at three hospitals from July 2013 to July 2019. Kaplan-Meier analysis was used to calculate overall survival (OS), the log-rank test was used to compare the survival rate between groups, and a multivariate Cox proportional hazards model was constructed to estimate the hazard ratios (HRs) of independent prognostic factors. Results: The one-year, three-year, and five-year OS of 229 children was 90.9, 83.0, and 79.7%, respectively. Multivariate analysis revealed that age >96 months, metastasis, antiplatelet therapy, and AFP<100ng/ml were independent risk factors for OS, while tumor rupture and PLT >450x10 9/L were not. Among the intermediate-risk children in the high platelet group, the survival rate after antiplatelet therapy was 52.3±6.1%, which was significantly lower than that following non-antiplatelet therapy (82.6±5.1%) ( P=0.036). Conclusion: Our findings confirm that secondary thrombocytosis is not an independent risk factor of OS in HB. We don’t recommend antiplatelet therapy for children with hepatoblastoma combined with secondary thrombocytosis.
ALLEVIATION OF SOIL SALINITY EMPLOYING ORGANIC AMENDMENTS TO RESTORE FERTILITY AND SU...
Ajay Neeraj
R.Y. Hiranmai

Ajay Neeraj

and 1 more

July 20, 2022
Agricultural practices modified the soil quality considerably inputs to the soil in terms of irrigation, fertilizer, and crop variety influenced soil fertility. The quality and quantity of irrigating water modify soil’s physical, chemical, and biological properties and productivity. Soil is affected by natural and anthropogenic activities, and it is reflected in different agricultural lands. Salinity is one of the significant issues affecting agriculture by; increasing the soil salt content and modifying the mineral composition turn imbalances the organic matter, biotic community, and biogeochemical cycling. Agricultural, domestic, and industrial activities produce various organic wastes recycled for soil quality improvement. These organic sources can be converted to organic matter of soil and balance exchangeable ions, and manage the soil properties. This review paper is prepared by referring to the research and review articles published in reputed journals concerning soil quality, salinity and reclamation of saline soil using organic wastes, composts, vermicompost and organic matter. The comprehensive study of research exhibits that the organic matter from the biowastes can be a resource for modifying the saline soil and improving crop production.
Can SIF and NPQ be used in the photosynthesis rate simulation of plants subjected to...
Shaomin Shi
Sen Lu

Shaomin Shi

and 5 more

July 20, 2022
Solar-induced chlorophyll fluorescence (SIF) has been used to estimate leaf-level net CO 2 assimilation by a mechanistic light reaction (MLR-SIF) equation. However, the application of this model would be limited by the challenging measurement and estimation of input parameters (e.g. fraction of open PSII reaction centres, q L). We modified the MLR-SIF model by replacing q L by the easily obtained parameters (non-photochemical quenching [NPQ]) to facilitate its application. We employed synchronous measurements of gas exchanges, ChlF parameters and SIF for Leymus chinensis, Populus tomentosa Carrières and Ulmus pumila var. sabulosa under the soil–water deficit and rehydration process to test the robustness of the modified MLR-SIF model. Our results demonstrated that for L. chinensis the net photosynthesis rate dynamics under severe soil–water stress and saturated water condition were effectively captured by the modified MLR-SIF model ( R 2 = 0.75–0.92, RMSE = 1.11–3.56) . For P. tomentosa Carrières and U. pumila var. sabulosa, the net photosynthesis rates were predicted by the modified MLR-SIF model with good accuracy ( R 2 = 0.86, RMSE = 9.44; R 2 = 0.88, RMSE = 4.16) across the water deficit and rehydration condition . However, the electron transport rate estimated by the modified MLR-SIF model uncoupled with the photosynthetic capacity ( r 2 = -0.13) and lowered the net photosynthesis rate simulation precision ( R 2 = 0.35, RMSE = 3.41) for L. chinensis under mild drought stress and saturated light intensities. The electron transport rate estimated by the modified MLR-SIF model downregulated the photosynthetic capacity for P. tomentosa Carrières ( r 2 = 0.32) and U. pumila var. sabulosa ( r 2 = 0.22) under mild drought stress. The shift of the Rubisco and RUBP limited state cross-points, the dynamic photosynthesis parameters across the plant species and the alternative electron sinks under soil–water deficit and rehydration process influenced the simulation precision of the modified MLR-SIF model. Our modified MLR-SIF model provided a basis for understanding and inferring the photosynthetic rate by SIF and NPQ under water stress.
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