This paper presents the load-dependent power loss in a wind turbine gearbox under real-time operating wind speed for three different oil formulations. The gear power loss was determined using mathematical models from the values of gear loss factors and specific film thickness experimentally determined by other researchers. The bearing power loss was determined using the new SKF calibrated model. Wind data from Bafoussam, a town in Cameroon was used to validate the model. A back propagation neural network with different numbers of hidden neurons was designed for power loss modeling and prediction. The achieved results reveal that the load-dependent power loss in a wind turbine gearbox is greatly influenced by wind speed and oil type. Finally, it is shown that the predictive performance of the neural network is also influenced by the number of neurons in the hidden layer.

Primary abdominal ectopic pregnancy is extremely rare. This case write-up is to report a primary abdominal ectopic pregnancy managed with surgical intervention followed by medical treatment. Every gynecologist needs to have a high index of suspicion and deal promptly to obviate grievous consequences.

We present a case of a 61-years old female patient with family history of malignancy who presented with multiple nodules at the ultrasonography images. CT scan and MRI were not sufficient to pose a certain diagnosis which was later confirmed by liver biopsy.

Rust fungi are characterized by large genomes with high repeat content, and have two haploid nuclei in most life stages, which makes achieving high-quality genome assemblies challenging. Here, we describe a pipeline using HiFi reads and Hi-C data to assemble a gigabase-sized fungal pathogen, Puccinia polysora f.sp. zeae, to haplotype-phased and chromosome-scale. The final assembled genome is 1.71 Gbp, with ~850 Mbp and 18 chromosomes in each haplotype, being currently the largest fungal genome assembled to chromosome scale. Transcript-based annotation identified 47,512 genes with a similar number for each haplotype. A high level of interhaplotype variation was found with 10% haplotype-specific BUSCO genes, 5.8 SNPs/kbp, and structural variation accounting for 3% of the genome size. The P. polysora genome displayed over 85% repeat content, with genome-size expansion, gene losses and gene family expansions suggested by multiple copies of species-specific orthogroups. Interestingly, these features did not affect overall synteny with other Puccinia species with smaller genomes. Fine-time-point transcriptomics revealed seven clusters of co-expressed secreted proteins that are conserved between two haplotypes. The fact that candidate effectors interspersed with all genes indicated the absence of a “two-speed genome” evolution in P. polysora. Genome resequencing of 79 additional isolates revealed a clonal population structure of P. polysora in China with low geographic differentiation. Nevertheless, a minor population drifted from the major population by having mutations on secreted proteins including AvrRppC, indicating the ongoing evolution and population differentiation. The high-quality assembly provides valuable genomic resources for future studies on the evolution of P. polysora.

In order to interpret the degree of postmating isolation and the evolutionary relationships among Fejervarya species from Indonesia (Lesser Sunda), Bangladesh, China, and Japan, crossing experiments and molecular phylogenetic analyses were carried out using frogs of Fejervarya species from these countries. The crossing experiments revealed that the reciprocal hybrids among F. iskandari, F. verruculosa, and F. sp. Large type, and those between F. multistriata and F. kawamurai were viable through metamorphosis, but those between F. iskandari group and F. limnocharis group were completely or partially inviable at the tadpole stage, and those between Southeast -Asian and South-Asian Fejervarya groups were completely inviable at the embryonic stage. The matured reciprocal hybrids between F. iskandari and F. verruculosa from Indonesia, Lesser Sunda showed some degree of abnormality in spermatogenesis. The phylogenetic analyses using mtDNA Cytb gene sequences demonstrated that F. iskandari formed a sister clade with F. verruculosa from Lesser Sunda, Indonesia with 8.1% sequence divergence. Fejervaraya multistriata from China made a clade with Thailand, Malaysia and Indonesian (topotype) populations of F. limnocharis which showed sister relationships to F. kawamurai from Japan with 8.9% sequence divergence of Cytb gene. Fejervarya sp. small type from Bangladesh formed a clade with the other South-Asian members of Fejervarya group and made a sister clade with Southeast-Asian Fejervarya group having 23.1% sequence divergence of Cytb gene. This study showed that the degree of postmating isolation reflects the molecular phylogenetic relationships, and that the two species, F. iskandari and F. verruculosa from Indonesia (Lesser Sunda) are reproductively isolated by abnormal spermatogenesis, and genetically deviated.

Malignant hyperthermia (MH) is a lethal complication associated with general anesthesia characterized by sudden onset, rapid progression, and high mortality. Adequate preoperative assessment, attention to MH susceptibility, early identification of MH response, timely rescue, early use of dantrolene, and attention during cardiopulmonary bypass are necessary for comprehensive MH treatment.

We described a case of neural tube defect (NTDs) viz., occipital encephalomeningocele born to a mother with folic acid supplementation. A wide interplay of genetic and environmental factors exists in its causation. The folic acid confers advantage but the relationship with causation of NTDs is still not clear.

Background: In the absence of a clear clinical history of reaction, diagnosis of cashew allergy using skin prick tests (SPT) or cashew-specific IgE requires a high number of oral food challenges (OFC). By using Ana o 3 sIgE alone, or a two-step diagnostic algorithm using cashew sIgE followed by Ana o 3 sIgE, there is a reduced need for OFC. We aimed to perform a cost comparison for both of these approaches compared to cashew SPT alone. Methods: Pooled individual level data from 6 studies was used to determine diagnostic accuracy and OFC rate. Two studies used cashew SPT (n=567, 198 allergic), with 95% positive and negative predictive values of ≥12mm and <3mm. Four studies were included in the pathways for Ana o 3 sIgE alone or a 2-step algorithm incorporating cashew and Ana o 3 sIgE (n=271, 156 allergic). Cut-offs used were ≥8.5kUA/L and ≤0.1kUA/L for cashew sIgE and ≥0.35kUA/L and ≤0.1kUA/L for Ana o 3 sIgE. Costs were constructed based on unit prices from hospital inpatient admissions, expenses incurred by families, individual patient data on allergic reaction types and rates and adrenaline autoinjector carriage, applying a health system perspective. Results: Modelled data through the Ana o 3 pathway resulted in a 46.43% cost reduction (\euro307,406/1000 patients) compared to using cashew SPT alone (\euro573,854/1000 patients). The 2-step algorithm resulted in a 44.94% cost reduction compared to SPT alone (\euro315,952.82/1000 patients). Both the Ana o 3 pathway and 2-step algorithm resulted in a 79-80% reduction in OFCs compared to SPT. Conclusions: Using Ana o 3 as a standalone test for cashew allergy diagnosis or a 2-step algorithm incorporating cashew sIgE and Ana o 3 sIgE is accurate and results in a large reduction in both OFCs and health system costs compared to cashew SPT alone.

Children with congenital neutropenia frequently require hospitalization due to febrile neutropenia. Deficiency of Adenosine DeAminase -2(DADA-2) an autosomal recessive disorder caused by a mutation in CECR1 gene. It is an autoinflammatory disease presenting with autoimmunity and features of immunodeficiency. It usually presents in early childhood with recurrent stroke and vasculitis features. Here, we report a young male with CECR1 mutation presenting predominantly with neutropenia.

n this work, we present a new boundary conditions for fractional cubic spline (FCS) model for solving fractional Volterra-integral equations. We reduced the problem to a set of a linear systems by using fractional continuity conditions. Convergence analysis proved to solve fractional Volterra-integral equations by obtained linear systems, to determine fractional spline derivatives, we applied the Caputo fractional derivative. The process is detailed and computed with three computational examples, and the results show that it is both effective and simple to use. Moreover, the results are compared with the methods in [1 ], [ 2 ] and [4].

Ab initio calculations were carried out to understand the effect of electron donating groups (EDG) and electron withdrawing groups (EWG) at the C5 position of cytosine (Cyt) and saturated cytosine (H2Cyt) of the deamination reaction. Geometries of the reactants, transition states, intermediates, and products were fully optimized at the B3LYP/6-31G(d,p) level in the gas phase as this level of theory has been found to agree very well with G3 theories. Activation energies, enthalpies, and Gibbs energies of activation along with the thermodynamic properties (ΔE, ΔH, and ΔG) of each reaction were calculated. A plot of the Gibbs energies of activation (ΔG‡) for C5 substituted Cyt and H2Cyt against the Hammett σ-constants reveal a good linear relationship. In general, both EDG and EWG substituents at the C5 position in Cyt results in higher ΔG‡ and lower σ values compared to those of H2Cyt deamination reactions. C5 alkyl substituents (−H, −CH3, −CH2CH3, −CH2CH2CH3) increase ΔG‡ values for Cyt, while the same substituents decrease ΔG‡ values for H2Cyt which is likely due to steric effects. However, the Hammett σ-constants were found to decrease for both the Cyt and H2Cyt. Both ΔG‡ and σ values decrease for the substituents Cl and Br in the reaction Cyt, while ΔG‡ values increase and σ decrease in the reaction H2Cyt. This may be due to high polarizability of bromine which results in a greater stabilization of the transition state in the case of bromine compared to chlorine. Regardless of the substituent at C5, the positive charge on C4 is greater in the TS compared to the reactant complex for both the Cyt and H2Cyt. Moreover, as the charges on C4 in the TS increase compared to reactant, ΔG‡ also increase for the C5 alkyl substituents (-H, −CH3, −CH2CH3, −CH2CH2CH3) in Cyt, while ΔG‡ decrease in H2Cyt. In addition, analysis of the frontier MO energies for the transition state structures shows that there is a correlation between the energy of the HOMO‒LUMO gap and activation energies.

Rhabdomyosarcomas (RMS) are the most common pediatric soft tissue sarcomas. High-risk and metastatic disease continues to be associated with very poor prognosis. RMS model systems that faithfully recapitulate the human disease and provide rapid, cost-efficient estimates of anti-tumor efficacy of candidate drugs are needed to facilitate drug development and personalized medicine approaches. Here, we present a new zebrafish-based xenotransplant model allowing for rapid and easily accessible drug screening using low numbers of viable tumor cells and relatively small amounts of water-soluble chemicals. Under optimized temperature conditions, embryonal RMS-xenografts were established in zebrafish embryos at 3 hours post fertilization (hpf). In proof-of-principle experiments, chemotherapy drugs with established clinical anti-RMS efficacy (vincristine, dactinomycin) and the MEK inhibitor trametinib were shown to significantly reduce the cross-sectional area of the tumors by 120 hpf. RMS xenograft models in zebrafish embryos henceforth could serve as a valuable addition to cell culture and mammalian models of RMS and represent a rapid and cost-effective solution for pre-clinical candidate drug testing.

This paper studies different kinds of stability and finite/fixed-time attractivity problems for time-delayed Filippov system (TDFS) via time-delayed differential inclusions(TDDI). A series of novel criteria concerning basic stability and finite/fixed-time attractivity for TDFS are established by employing indefinite Lyapunov method. As an application, the problems of stabilization and attractivity in finite/fixed time are explored for delayed switched neural networks (DSNNs), where four control protocols are developed. Furthermore, several concrete examples are given to demonstrate the effectiveness and advantages of the main results.

Hydrogen is regarded as one of the most potential sustainable energy sources in the future. applications including transportation. Still, the event of materials for its storage is difficult notably as a fuel in vehicular transport. Nanocones are a promising hydrogen storage material. Silicon, germanium, and tin carbide nanocones have recently been proposed as promising hydrogen storage materials. In the present study, we have investigated the hydrogen storage capacity of iC,GeC and SnC nanocones functionalized with Ni. The functionalized Ni a are found to be adsorbed on iCNC,GeCNC and SnCNC with an adsorption energy of -5.56, -6.70 and -4.25 eV. The functionalized iCNC,GeCNC and SnCNC bind up to seven, six and four molecules of hydrogen with the adsorption energy of (-0.34, -0.35 and -0.26 eV) and an average desorption temperature of around 434, 447 and 332K (ideal for fuel cell applications). The SiC, GeC, and SnC nanocones systems exhibit a maximum gravimetric storage capacity of 12.51, 7.78 and 4.08 wt%. We suggested that Ni- SiCNC and Ni- GeCNC systems can act as potential H2 storage device materials because of their higher H2 uptake capacity as well as there with strong interaction adsorbed hydrogen molecules than Ni- SnCNC systems. The hydrogen storage reactions are characterized in terms of the charge transfer, the partial density of states (PDOS), frontier orbital band gaps, isosurface plots, and electrophilicity are calculated for the functionalized and hydrogenated SiC,GeC and SnC nanocones.

Any quantum groups can be filtered via PBW Theorem over a graded algebra where the structure representation for any supercommutator [𝗶,𝗷] when reduced asserts a linear monomial of a canonical origin. Thus, being independent on the swapping order, isomorphism can be seen for any injective takeovers giving the map ψ: ℓ ⟶ U(ℓ) with the Lie ℓ through the U(ℓ) group. This satisfies direct connectivity over 𝙊𝙨𝙥(𝙢,𝙣)⋂𝙊𝙨𝙥(𝙣,𝙢) in Kac-Moody algebras.

A Short-circuit protection plays a vital role in the overall reliability of intelligent power module(IPM), and where the shorter the duration of short-circuit fault, the smaller the impact on the module. The conventional VCE(sat) detection circuit suffers from a blanking time problem, and thus to solve this problem, this paper aims to improve the IPM short-circuit fast detection and protection circuit with integrated shunts, to achieve the ultra-fast detection and protection of IPM short-circuit faults. For the improved circuit, the selection method for the component parameters of a compensation link of the improved circuit is proposed, and the functions for the remaining parts in the circuit are introduced. Finally, through experiments, it is verified that the improved circuit can quickly detect various short-circuit faults, and correspondingly start shutting down the switching tube at 490ns. Compared with the conventional method, the detection time of the proposed method and short-circuit loss for modules under different short-circuit faults are significantly reduced.

Cytomegalovirus (CMV) retinitis is an uncommon presentation post allogeneic transplant and can be vision-threatening. This case demonstrates the occurrence of mixed viral retinitis (CMV and varicella zoster virus) post allogeneic stem cell transplant despite multiple prophylactic antiviral therapies, and features CMV retinitis in the absence of CMV DNAemia.

Standard convolution is difficult to provide an effective fog feature for visibility estimate tasks due to the fixed grid kernel structure. In this paper, a multiscale deformable convolution model (MDCM) is proposed to extract features that make effectively sampling discriminating features from the atmospheric region in foggy image. Moreover, to enhance performance we use RGB-IR image pair as observations and design a multimodal visibility range classification network based on the MDCM. Experimental results show that both the robustness and accuracy of visibility estimate performance are raised beyond 30% compared to standard convolutional neural networks (CNNs).

An ultra-wideband (UWB) antenna with dual band-notched characteristics is proposed in this letter. The fabricated prototype of the proposed antenna has a compact size of 30×24mm which operates at 3GHz to 11GHz and attained dual notch-bands at 3.3-3.7GHz and 5.15-5.825GHz. The result shows that the proposed antenna is compact, easy to fabricate and provides good characteristics in radiation patterns and time-domain behaviors. The simulated and measured results displayed good agreement over the entire operating frequency band. The proposed antenna can be used for wideband frequency requirement systems like indoor positioning.

H Syndrome is a rare genodermatosis. It may include facial involvement such as : facial telangiectasia, both hypo- and hyperpigmented lesions, hirsutism, swollen cheeks due to subcutaneous infiltration and eczematous lesions. We describe a new facial phenotype with dermoscopic and histological features in the spectrum of non-Langerhans cell histiocytosis.

Thalassemia is a well-understood genetic disorder, and routine genetic tests typically cover 95% of known genetic mutations. Discordance between the clinical phenotype and genotypes suggest that expanded genetic studies should be performed to look for rare mutations.We report two pregnant women at 17 week gestations. Routine laboratory and geneti

It is valuable that graphene-like porous carbon materials are prepared from the biomass resources due to theirs porous structure, heteroatom, and high specific surface area. Herein, we use egg white and graphene oxides as precursor and employ post-hydrothermal carbonization approach, freeze-drying technique, carbonization, and activation methods by KOH to prepare the graphite carbon nanoflakes with Fe7C3@graphite carbon nanoflakes hybrid materials. Morphology tests imply that the formation of graphite carbon nanoflakes are mainly depended by activation step, it implies that carbon flakes are exfoliated via introducing K+ into carbon layers and further destroying the van der Waals force (VDWF). As a result, this hybrid materials exhibit a attractive capacitance (528 mF·cm-2@1 mA·cm-2) and durability (91@10 mA·cm-2, 4000 cycles). For hydrogen evolution reaction (HER), the as-collected samples also deliver a low overpotential and remarkable stability. We believes that the as-obtained hybrid materials have a greatly application value in energy storage devices.

In this work, the influence of polymeric excipients and relative humidity (RH) on stability of amorphous solid dispersions (ASDs) was investigated. Irbesartan and oxaprozin of BCS Ⅱ were selected as model active pharmaceutical ingredients (APIs). PVP and PVP/VA were chosen as model excipients. The water sorption and the physical stability of amorphous solid dispersions stored at constant temperature and humidity were measured. The thermodynamic phase diagrams were constructed using Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT) and Gordon-Taylor equation. The results showed that the hygroscopicity of PVP-containing was stronger than PVP/VA-containing. The water sorption was found to significantly decrease the API solubility in the polymer as well as the glass-transition temperature of the formulation. The solubility of irbesartan and oxaprozin in PVP and PVP/VA were further predicted at 25 °C with PC-SAFT. It could guide the design of amorphous solid dispersions and selection of storage conditions.

Biological soil crust (BSC), as a groundcover, is widely intergrown with grass. The combined effects of BSC and grass during rainfall on runoff and sediment yield are still unclear. In this study, simulated rainfall experiments were applied to a soil flume with four different slope cover treatments, namely, bare (CK) and Stipa bungeana Train. (STBU), BSC, and STBU + BSC to observe the processes of runoff and sediment yield. Additionally, the soil moisture at different depths during infiltration was observed. The results showed that the runoff generated by rainfall for all treatments was in the following order: BSC>STBU+BSC>CK>STBU. Compared with CK, the STBU promoted infiltration, and BSC and STBU+BSC inhibited infiltration. The BSCs obviously inhibited infiltration at a depth of 8 cm. As the soil depth increased to 16 cm and 24 cm, the effects of STBU on promoting infiltration were stronger than those of BSC on inhibiting infiltration. Compared with the CK, the flow velocity for the BSC, STBU and STBU + BSC treatments was reduced by 62.79%, 32.27% and 68.29%, respectively. The BSC and STBU increased the critical shear stress by increasing the resistance. Additionally, the BSC, STBU and STBU+BSC treatments reduced the sediment yield rate by 80.8%, 99.8% and 99.9%, respectively. The soil erosion process was dominated by the soil detachment capacity in the CK, BSC and STBU+BSC treatments, while the STBU treatment showed a transport-limited process. This study provided a scientific basis for the reasonable spatial allocation of vegetation in arid and semiarid areas and provided a scientific basis for the correction of vegetation cover factors in soil erosion prediction models.