Cryptococcus neoformans infection is a known cause of meningoencephalitis in immunocompromised patients. However, it is less frequent in immunocompetent individuals. Here we report a case of a 60 years old COVID-19 patient with a history of several co-morbidities who received tocilizumab and corticosteroids, which lead to Cryptococcemia.
A 60-year-old man presented to our hospital with pericardial effusion. He died of respiratory failure 13 months later. Autopsy revealed right atrial angiosarcoma extending into the right lung. To the best of our knowledge, this is the first case report of a primary cardiac angiosarcoma that displayed direct lung invasion.
We present an 11-year-old female with persistent hypoglycemia in the setting of new-onset type I diabetes mellitus, with further diagnosis of both Hashimoto's thyroiditis and Addison's disease for a diagnosis of autoimmune polyglandular syndrome type II, an autosomal dominant syndrome. Three years later, the child's mother was subsequently diagnosed.
Keratosis lichenoides chronica (KLC) is a rare dermatosis which represents different clinical characteristics between adult- and pediatric-onset cases. We described a childhood case of KLC with features typical for adult onset disease. Acitretin led to partial improvement of her skin (but not mucosal) lesions.
We report on pregnant woman affected by NF1 and HIV infection. So far, both NF1 and HIV in pregnancy had never reported. During 7-year follow-up, she experienced 4 pregnancies without any complication linked to NF1. The newborns were HIV-negative. A multidisciplinary counseling could improve ante and post-partum management.
chylothorax is a relatively uncommon condition. It is characterized by the presence of chylous rich fluid within the pleural space. Spontaneous chylothorax usually refers to non-traumatic causes most common malignancy and infections. we present a case of a spontaneous chylothorax with evidence of resolution of pleural effusion without detectable cause.
The case report describes a newborn case of ACS based on clinical presentation(s) and microdeletions of 22q11.21 and 11p15.4 using DNA high throughput sequencing analysis. This finding has implications for ACS diagnosis and overcomes the limitations associated with FISH by using the DNA high throughput sequencing across the whole genome.
Although less common compared to postherpetic neuralgia, post herpes itch (PHI) is a known sequela after herpetic infections. PHI usually disappears over weeks to months, requiring only symptomatic management. Rarely, PHI can result in significant debilitation. We report one case of extreme post herpetic itching and review the available literature.
We are presenting a case of Necrobiosis Lipodica disease in a 55 year lady whose diabetes status was not known at the time of presentation in dermatology OPD. Traditionally, the diagnosis is confirmed by histopathological examination (HPE). Dermoscopy can also be used as a noninvasive tool to confirm the diagnosis.
Thrombocytosis is common in children with sickle cell disease (SCD). Reactive thrombocytosis must be distinguished from myeloproliferative disorder or inherited thrombocytosis syndrome. We present an adolescent with hemoglobin SS and thrombocytosis associated with increased frequency of pain, priapism, and acquired von Willebrand disease.
NTRK gene-fusions are rare but can occur in diverse cancers. The NTRK inhibitor larotrectinib is newly approved by the FDA. This paper reports the first case of a man with a NTRK-rearranged soft tissue sarcoma treated with larotrectinib in the neoadjuvant setting, in Belgium, to avoid limb amputation.
Temozolomide (TMZ) is a standard of care treatment for Glioblastoma Multiforme (GBM). We report a fatal outcome of a 55 years old female with GBM who developed persistent aplastic anemia (AA) while being treated with TMZ. This case highlights the possibility of a dose-independent and fatal AA secondary to TMZ.
We report a 56-year-old male with methemoglobinemia and hemolytic anemia, secondary to fava bean ingestion. Methylene blue administration worsened the hemolysis as he was G6PD deficient but not diagnosed before. We have discussed the mechanism of hemolysis in such patients and the management of such cases.
Dapsone had been used for leprosy but now used in dermatological conditions. The medical emergency team saw a patient on Dapsone with low oxygen saturation despite 8L/min O2 and elevated methaemoglobin level. After diagnosising dapsone related methaemoglobinaemia dapsone was ceased and Vitamin C given intravenously for 4 days