Crecutzfeldt-Jakob disease (CJD) is a rare, fatal, and devastating neurodegenerative disease，It is not well recognized and increasingly underdiagnosed due to its variant clinical presentations. Here we report a case of probable sporadic CJD in a woman with dizziness as initial symptom and misdiagnosed as acute cerebral infarction.
Three patients with COVID-19 pneumonia received treatment with hydroxychloroquine combined with lopinavir plus ritonavir and favipiravir. Two patients early diagnosed with COVID-19 pneumonia received tocilizumab at severe pneumonia diagnosed and survived. The third patient was late diagnosed and received tocilizumab when the disease progressed to ARDS, and passed away.
Overlap syndrome associating primary biliary cholangitis and autoimmune hepatitis remains a rarely studied pathology. The diagnosis is based on diagnostic criteria. The criteria of Chazouillères (Paris criterion) et al were the most used. The combination of UDCA and immunosuppressive helped achieve remission in the majority of cases.
Acute aortic dissection combined with cardiac tamponade is fatal. The radical treatment is an aortic replacement; however, the risk is high. The treatment method for elderly patients is difficult to determine. We suggest conservative treatment with pericardial drainage may be one of the treatment options in the elderly with comorbidities.
Ipilimumab has been associated to medication related jaw osteonecrosis (MRONJ) only two times in literature. A woman underwent therapy with ipilimumab for Metastatic Melanoma in 2015 and she developed MRONJ in 2018. She was successfully treated with medical therapy alone. Vigilance in dental management of these patients is needed.
The guidelines recommend surgical treatment for fulminant Clostridium difficile infection (CDI). However, mortality remains high, and patients with severe condition are not considered for surgical treatment because of poor post-surgical outcomes. Moreover, delayed diagnosis of fulminant CDI may induce intestinal necrosis. Thus, early diagnosis is crucial.
Erdheim–Chester disease (ECD) is a rare non-Langerhans disease. This the report describes a 51-year-old woman with a history of weakness, bone pain, xanthelasma palpebrarum, diabetes insipidus, and hypothyroidism. ECD is a multisystemic condition with a poor prognosis. This disease should be considered in patients with diabetes insipidus and multiorgan involvements.
Cardiac involvement in electrical injury is rare yet poses serious manifestations with high mortality rate. In most cases, symptoms occur immediately after the incident. We present a case of cardiac arrest six hours following uneventful electrocution. The case emphasis the potential late sequel of cardiac injury.
Olfactory and gustatory dysfunctions are common presentations in COVID-19 patients. We present three patients who received smell and taste tests after recovery. The smell test suspected persistent impairment of olfactory function in these patients. The report proposes continued evaluation of olfactory function by a smell test in COVID-19 patients.
In this case series, four patients developed or presented with severe infections. In addition to antimicrobial therapy, they were treated with a new matrix therapy technology called CACIPLIQ20®. CACIPLIQ20® markedly improved the outcomes of all cases in terms of healing times and range of motion despite healing by secondary intention.
Postpartum unscarred uterine ruptures are exceedingly rare. A 29-year-old multipara with a retained placenta presented hypovolemic shock. An emergency laparotomy revealed that her uterus was ruptured where the placenta adhered to. Pathological examination confirmed the placental accreta that could be a risk factor for postpartum unscarred uterine rupture.
A giant granuloma obstructing the upper airway in a 21-year-old male is described. It arose after an extreme psychological stress. The patient underwent microlaryngoscopic removal of the granuloma, with no recurrence. This case confirms the role of psychological stress in the pathogenesis of laryngeal granulomas, that can reach huge dimensions.