Temozolomide (TMZ) is a standard of care treatment for Glioblastoma Multiforme (GBM). We report a fatal outcome of a 55 years old female with GBM who developed persistent aplastic anemia (AA) while being treated with TMZ. This case highlights the possibility of a dose-independent and fatal AA secondary to TMZ.
We report a 56-year-old male with methemoglobinemia and hemolytic anemia, secondary to fava bean ingestion. Methylene blue administration worsened the hemolysis as he was G6PD deficient but not diagnosed before. We have discussed the mechanism of hemolysis in such patients and the management of such cases.
Dapsone had been used for leprosy but now used in dermatological conditions. The medical emergency team saw a patient on Dapsone with low oxygen saturation despite 8L/min O2 and elevated methaemoglobin level. After diagnosising dapsone related methaemoglobinaemia dapsone was ceased and Vitamin C given intravenously for 4 days
A steroid- and cyclosporine A- resistant case of Pfeiffer-Weber-Christian disease (PWCD) was remitted completely with sequential treatment with Histobulin and IVIG. The multiple food allergies and the atopic dermatitis of this PWCD patient were also improved with Histobulin treatment. The upper respiratory infections were improved by Histobulin therapy also.
Coronavirus-2019 (COVID-19) pandemic is a global health challenge where pregnant women are potentially more vulnerable to respiratory infections. We describe the successful management of a case a 35 years old pregnant woman, G3, P1, with a history of caesarian section who tested positive for COVID-19 and required critical care support
Natal teeth are the teeth present at birth, while neonatal teeth are those that erupted during the first month of life. Both are not uncommon anomalies with an incidence of 1:700 to 1:3500, respectively. Natal teeth occur more frequently than neonatal teeth at a ratio of approximately 3:1. Natal teeth
A fetus harboring a duplication of SMAD2 exons 1-6 presented with dextrocardia and pulmonary hypoplasia. Mate-pair sequencing revealed the duplication to be in inverted tandem orientation to the wild-type SMAD2 allele, disrupting its sequence and decreasing expression. These observations suggest SMAD2 to be responsible for the fetal dextrocardia.
Mucinous cystic neoplasm of the liver is a rare slow-growing lesion accounting for less than 5% of all hepatic cystic neoplasms. Differential diagnosis from other cystic lesions remains challenging despite progress achieved in the radiological modalities. Only histopathological examination of the surgical specimen establishes with certainty the diagnosis.
We report a rare percutaneous intervention to the Left Anterior Descending (LAD) and Right Coronary Artery (RCA) bifurcation in a 77 year old with anomalous origin of the RCA from mid LAD and Medina 1,1,1 bifurcation disease. The LAD/RCA bifurcation lesion was successfully treated using Mini crush technique.
Proposal for safe eradication therapy of Helicobacter pylori in patients with porphyria Tadayuki Takata, MD, PhDa,b*, Yohei Kokudo, MDc, Asahiro Morishita, MD, PhDd, Kodai Kume, MD, PhDb, Tatsuo Yachida, MD, PhDd, Masaki Kamada, MD, PhDc, Hideki Kobara, MD, PhDd, Kazushi Deguchi, MD, PhDb, Tetsuo Touge, MD, PhDe, Hisashi Masugata, MD, PhDa, Tsutomu Masaki, MD, PhDd
We found no significant differences in platelet function in patients with severe HA in prophylactic treatment before and after FVIII infusion. After FVIII administration, patients presented fewer endothelial microvesicles, indicating that the treatment does not increase one of the possible thrombotic risk markers of these patients.
COVID-19 related pneumonia overlaps with ACS, one of the most common acute presentations in SCD patients.We present a case of 22-year-old SCD patient presented to the emergency department with mild respiratory symptoms turned out to be COVID-19 positive and received red blood cell exchange to avoid the possibility of deterioration.
An 80 year old woman underwent vitrectomy for recurrent uveitis, demonstrating lymphocytic vitreous fluid. Less than a month later skin biopsy confirmed the diagnosis of extranodal NK/T cell lymphoma. Chemotherapy with SMILE (steroid - dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide) was poorly tolerated despite reduced doses, while pembrolizumab was ineffective.
Hand and foot syndrome (HFS) is a toxic dermatologic reaction to chemotherapy, commonly described with capecitabine, 5fluouracile, vinorelbine, and cytarabine. Taxanes are less likely to induce HFS, and very few cases reported paclitaxel-induced HFS. We report a serious case of HFS induced by paclitaxel in a breast cancer female.
Background: Mediastinal cystic teratoma is a rare diagnosis in adolescence from low-income setting. Pleural effusion often mislead to infection and delay resection. We report a case from high burden tuberculosis country and analyze data from the literature. Methods: Clinical record of an adolescent patient from the Democratic Republic of Congo