We report the case of a 14-year-old girl with pain and protrusion of the left eye and treated with Diclofenac. Clinical and paraclinical examinations revealed a cerebral empyema and a left retro-orbital abscess complicating an acute ethmoiditis. The delay in diagnosis would have led to the occurrence of these complications.
Lung adenocarcinoma (LA) is the most common subtype of lung cancer with non-significant manifestations. Some benign conditions can mimic LA in symptoms and even chest imaging. In this case report, we are discussing a young man without any significant past medical history with metastatic LA, initially presumed military TB.
IntroductionEculizumab is a fully humanized monoclonal blocking antibody to complement protein C5 that inhibits cleavage to C5a and C5b, thus preventing terminal complement complex C5b-9 and formation of the membrane attack complex.1 Eculizumab was FDA approved in 2020 for the treatment of neuromyelitis optica (NMO) after it was shown to be effective in reducing relapse frequency in highly clinically active, aquaporin-4 immunoglobulin G (AQP4-IgG)-positive NMO.2 Commonly reported side effects (>10%) include upper respiratory infections and headache. A life-threatening desquamating rash and hyperammonemia following administration of eculizumab for paroxysmal nocturnal hemoglobinuria (PNH) has been reported.3 Cutaneous adverse drug reactions can range from self-limited cutaneous eruptions such as maculopapular exanthema to severe cutaneous drug reactions. Severe cutaneous adverse reactions are rare, potentially life-threatening, and T-cell mediated hypersensitivity reactions.4 Certain drugs can induce autoantibodies rather than cause an autoantibody-associated disease. The information available suggests eculizumab is unlikely to do this.5 We report a patient with refractory NMO who developed a cutaneous drug reaction following intravenous eculizumab administration. This information will be useful to clinicians, given the expanding clinical uses of eculizumab in diseases such as atypical hemolytic uremic syndrome (aHUS), PNH, and myasthenia gravis.6-8 Eculizumab has also been used for lupus nephritis-associated thrombotic microangiopathy in systemic lupus erythematosus patients.9
Necrolytic Acral Erythema (NAE) is a rare cutaneous sign for hepatitis C virus, which generally presents as circumscribed keratotic plaques on the extremities. Many studies reported NAE in the absence of HCV. This case presents a female diagnosed with NAE and hypothyroidism in the absence of HCV infection.
Cardiac bradyarrhythmia and conduction disorder may be rare, but recurrent adverse events caused by bortezomib. Here we report a case with POEMS syndrome presenting severe heart block after bortezomib plus dexamethasone therapy. After permanent pacemaker implantation, bortezomib was restarted and maintained, resulting in sustained complete response for POEMS syndrome.
The dentigerous cyst is frequent in children under 12 years old. Surgical marsupialization or decompression are actually the most two conservative treatment option described for the management of dentigerous cyst with the preservation of involved teeth. we report two clinical cases of dentigerous cysts treated successufelly by decompression
Synovial chondromatosis is a rare benign condition characterized by chondral proliferation from synovium forming loose bodies which can occur extra-articularly and intra-articularly. Surgical removal remains the mainstay of treatment for synovial chondromatosis. Due to the risk of recurrence, every case must be followed up with an MRI.
We report the case of a 33-year-old man with a self-inflicted neck wound with severe hypopharynx injury, and hemorrhagic shock, which was well-managed by a trauma surgeon trained in esophageal surgery. Training in cervical lymph node dissection for esophageal cancer could be useful for management of penetrating neck injuries.
Bell's palsy is an acute peripheral facial paralysis commonly associated with viral infections. COVID-19 may be a potential cause of peripheral facial paralysis and other neurological manifestations. We report a case of Bell's palsy due to COVID-19 infection in a previously healthy 35 -year- old male.
Coronavirus disease 2019 (COVID-19) can cause various complications. Pneumothorax secondary to COVID-19 is relatively uncommon and bilateral pneumothorax is even more so. In patients with poor general health to undergo surgery for pneumothorax, internal treatments are essential to relieving refractory pneumothorax.
67-year-old presented with subacute left temporal lobe infarction, lumbar spine osteomyelitis, and aortic valve vegetation. Further investigations demonstrated Abiotrophia defectiva bacteremia. He was treated with penicillin and gentamicin, discharged with 4 weeks ceftriaxone. We wish to raise awareness of complications of A. defectiva endocarditis and encourage further research into treatment.
Intestinal atresia and Hirschsprung disease are two common causes of bowel obstruction in neonates,simultaneous occurrence is rare. This report delineates a 36-week newborn with ileal atresia and total colonic Hirschsprung who was referred to our unit due to failure of meconium passage during the first 48 hours after birth
Although rare, the association between simple bone cysts and cemento-osseous dysplasia is very important to know. It is essential to be able to establish a correct diagnosis through regular follow-up to detect clinical and radiological changes of this entity over time and to be able to intervene when necessary.
Splenic cysts are very rare and are either primary or secondary.It is important to differentiate preoperatively with malignancies and hydatid cysts.Management options are either splenectomy or spleen preserving.We present this case because of its clinical rarity, diagnostic dilemma and histopathological diagnosis of pseudocyst in the absence of trauma.
Intussusception is a surgical emergency. If not immediately treated, it can lead to bowel wall perforation. In 2.2-15% of cases, they have pathologic lead points such as Intestinal duplication. This case report presents a rare tubular ileal duplication as a necrotic Ileoileal intussusception in a 4-year-old girl.