Pemphigus Vulgaris Presenting with Epigastric PainAuthors: Marawan Elmassry MD1, Jerapas Thongpiya MD1, Pitchaporn Yingchoncharoen MD1, Jali Garza MS1, Matthew Soape MD2, Kanak Das MD11Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA2Department of Gastroenterology, Covenant Medical Center, Lubbock, TX, USA
Chronic Diarrhea as a Presentation of Behçet’s DiseaseMarawan Elmassry MD1*, Sayed Matar MD2, Jerapas Thongpiya MD1, Pitchaporn Yingchoncharoen MD1, Mostafa Abohelwa MD1, Sameer Islam MD31-Department of Internal Medicine, Texas Tech university Health Sciences Centre, Lubbock, TX, USA.2- Department of Pathology, Brigham and Women Hospital, Harvard Medical School, Boston, MA, USA.3- Department of Gastroenterology and Hepatology, Texas Tech university Health Sciences Centre, Lubbock, TX, USA.*Corresponding Author: Marawan Elmassry MDTexas Tech University Health Sciences Centre at Lubbock, Texas, USA.3601 4th street, Lubbock, TX 79430.Telephone/ Fax: +1-806-773-2831E-mail: Marawan.email@example.comConflict of interest: The authors have no financial conflicts to disclose.Patient’s consent: Written informed consent was obtained from the patient to publish this report in accordance with the journal’s patient consent policy.
We present a 35-year-old male who sustained a right hip GSI. Delayed THA with a two-step sequential approach is feasible management in this situation in order to manage soft tissue and decrease infection rate. At one-year follow-up visit the pain was relieved and function improved significantly and had no complaints.
Variation in Location of the Distobuccal Root Canal in a permanent Maxillary Second Molar: A Case Report and Literature ReviewABSTRACTThis case report describes the unusual location of the distobuccal root canal in a maxillary second molar with root fusion. On access opening, three distinct root canal orifices, the mesiobuccal canal, palatal canal, and a third orifice closer to the palatal canal, were seen, giving an illusion of an additional palatal canal. An attempt was made to search for the distobuccal canal in its usual position, leading to the gouging of the pulp chamber floor. An intra-operative limited field of view cone-beam computed tomography (CBCT) revealed the root orifice adjacent to the palatal canal was the distobuccal canal. CBCT also revealed fusion of both the buccal and palatal roots in the root’s coronal and middle third region, but they were not fused apically.Keywords: cone-beam computed tomography, distobuccal, fused roots, maxillary second molar, variation.INTRODUCTIONThe root canal system is highly complex and variable.1Numerous case reports and earlier studies have reported variations in maxillary molars.2-4 Variations have been mostly reported in the form of extra canals being present. However, Zhanget al., in an in-vitro study, found maxillary second molars to have more variations than the first molars.5 Most of the earlier studies have focused on the Mesiobuccal (MB) root of the maxillary first molar, as it frequently has two root canals with variations in the root canal pattern.6,7The case reports published in the literature pertaining to the variations in maxillary second molar are most frequently in relation to the alterations in the number of roots or root canals. Kottor et al. reported a case of a maxillary second molar with five roots and five separate canals in each of these roots.8 In contrast, Ahuja et al. reported a case of a maxillary second molar with a single root and single canal.9Regarding the distobuccal (DB) root canal, variations have been reported in the form of one additional canal (DB2) being present or fused with the MB canal. Fusion can also occur between one or both the buccal roots with the palatal (P) root.10-14 Fusion of the roots is more common in maxillary second molars, which could result in complete or partial fusion of the root canals.15,16For successful endodontic treatment, clinicians should be aware of the variations in the number of roots and root canals and the peculiar or eccentric location of root canals as described in this case report. This case report highlights the anatomic variation of the distobuccal root canal in a maxillary second molar and its management with the aid of an intra-operative limited field of view (FOV) Cone-beam computed tomography (CBCT), along with a literature review of variations reported in distobuccal roots and root canals in human maxillary second molar. The case presentation is based on the Preferred Reporting Items for Case reports in Endodontics (PRICE) 2020 guidelines.17CASE PRESENTATIONA 34-year-old male patient reported to the department with a chief complaint of pain in his upper left back tooth for the past ten days. History revealed an intermittent, localized throbbing type of pain, occurring during the night and aggravated during mastication. The patient’s medical history was non-contributory. Clinical intra-oral examination revealed deep occlusal caries in the maxillary left second molar (27) with tenderness to percussion. The tooth had an old amalgam restoration on the occlusal surface. The tooth mobility was within physiological limits, and the gingival attachment apparatus was normal. Thermal and electric pulp testing (Parkel Electronics Division, Farmingdale, New York, USA) elicited a negative response. The preoperative intraoral periapical radiograph (IOPA) revealed occlusal radiolucency involving pulp space with no periapical radiolucency (Figure 1A, 1B). Extra orally, no swelling was noticed. From the clinical and radiographic findings, a diagnosis of pulpal necrosis with symptomatic apical periodontitis was made, and endodontic treatment was initiated after obtaining consent from the patient.The tooth was anesthetized by using 1.8 ml (30 mg) of 2% lidocaine containing 1:200,000 epinephrine (AstraZeneca Pharma India Ltd., Bengaluru, India). Isolation was done using a rubber dam (Coltene Whaledent, Inc., Ohio, USA), and access opening was initiated using an endo access bur (#1) in high speed (Dentsply Sirona, Tulsa, USA) under a dental operating microscope (Prisma DNT Microscope, Labo America, Inc., California, USA). The pulp chamber floor examination with a DG-16 endodontic explorer (Hu-Friedy, Chicago, USA) revealed three distinct root canal orifices, the MB canal, and P canal, and another orifice in close approximation to the P canal, giving an illusion of an additional P canal (Figure 1C). An attempt was made to search for the DB canal in its usual position, but without success, this led to the gouging of the floor in that area (Figure 1C). As the DB canal was not identified in its usual location and a canal orifice was seen unusually placed between the buccal and P canal, an intra-operative limited FOV-CBCT was taken after obtaining consent from the patient. CBCT images of the maxillary second molar revealed fusion of both the buccal and palatal roots in the coronal and middle third region of the root, but apically they were separate. CBCT images confirmed the canal adjacent to the P orifice to be the DB canal. Even though the roots were fused partially, the canals remained separate (Figure 2A to 2F). The coronal section of the tooth in the CBCT scan also revealed early periapical radiolucency in the palatal root, which was not evident in the two-dimensional IOPA (Figure 2D). Working length was determined using IOPA and an electronic apex locator (Root ZX; Morita, Tokyo, Japan). Shaping and cleaning were performed using ProTaper Gold (Dentsply Maillefer, Ballaigues, Switzerland) and the crown-down technique. The MB and DB canals were enlarged to ProTaper F2 (25/08), and the P canal was enlarged until ProTaper F3 (30/09). The instrumentation was performed using 2.5% sodium hypochlorite solution and normal saline. Final irrigation was performed with 2.5 % sodium hypochlorite solution (Sisco Research Laboratories Pvt. Ltd., Mumbai, India), 17% EDTA (Prime Dental Product Pvt Ltd, Mumbai, India), and normal saline. The canals were medicated with Calcium hydroxide paste (Calcicur, VOCO, Cuxhaven, Germany) using a lentulo spiral (Dentsply Maillefer, Ballaigues, Switzerland), and the access cavity was sealed with Cavit (3M ESPE Dental Products, St Paul, MN, USA). The patient was asymptomatic during recall after 2 weeks. Calcium hydroxide was removed, and obturation was done by single cone obturation technique using F2 and F3 Gutta-percha (Dentsply Maillefer, Ballaigues, Switzerland) and AH plus resin sealer (Dentsply Maillefer Company, Tulsa, OK, USA) (Figure 3A). The access cavity was sealed using resin composite (Z-100; 3M ESPE Dental Products, St Paul, MN). The patient was asymptomatic during a follow-up period of 1 year (Figure 3B).DISCUSSIONRoot fusion occurs due to disturbance in Hertwig’s epithelial root sheath during developmental stages. It can also occur due to fusion in the furcation area or deposition of cementum over time.18 Root fusion is a common entity in maxillary second molars compared to the first molars.4 Fusion of roots can result in partial or complete fusion of the root canals and can lead to intra-canal communications or canal divisions that are challenging to shape and clean.19In this case report, the root canals remained separate without any communication. Based on Zhang et al. classification for fused roots in maxillary second molars, this tooth can be classified as a Type 5 pattern where the P root fused with MB and DB root.15 According to the recent classification of anomalies by Ahmed et al. , it can be classified as (RF5)327MB/DB/P.20In maxillary second molars, the three roots are grouped closer together, making the orifices form a flat triangle to almost a straight line. DB orifice is closer to the MB orifice and is usually located in the midpoint when a line is drawn from the MB to P orifices (Figure 4A).21 However, there are few cases reports on the variation of DB roots or root canals (Table 1). These variations are in the form of an extra root or root canal present close to the main DB canal. Variations in the DB root canals in literature are also present in the form of partial or complete fusion to either MB or P canals forming C-shaped canals or fusions leading to double or single-rooted maxillary second molars.8-14 These case reports also point to the fact that when a root canal orifice deviates from its actual position, there always is a need for careful inspection and exploration for possible additional canals.In the present case report, the search for the DB canal in its usual position led to the gouging of the pulpal floor. The intraoperative CBCT revealed that the roots were fused in the coronal and middle third, with the DB root placed palatally. Hence, the peculiar canal located just buccal to the P root canal orifice was the DB canal, which seemed to give an illusion of an additional P canal (Figure 4B). All three root canals also showed Vertucci Type I root canal pattern with no intra-canal communications with each other. To the best of our knowledge, no case report on such peculiarity in the position of the DB canal orifice has yet been published in the literature.In an earlier study by Han et al . done in the Chinese population, the average distance between the DB and P canals was 3-5mm, and between MB and DB canals was 1.5-3mm.22 The distance between the DB and P orifice was only 0.6mm, and between DB and MB orifice was 3.9mm in the present case when calculated using the measuring tool in the CBCT software (Planmeca Romexis version 5.2.0R). The smaller mesiodistal diameter of 8mm of the involved teeth, partial root fusion, and/or palatal positioning of the DB root could have been the possible reason(s) for the unusual position of the DB canal in the current case report.The spatial relationship between the roots and adjacent anatomical structures and the position and shape of anatomical structures inside the root to be treated is often difficult to assess using a conventional 2-D radiograph.23 Using CBCT in such complex cases enables us to understand the internal root canal anatomy better.24CONCLUSION Unusual root canal morphology of the maxillary molars is invariably a norm, and it should be visualized during the planning phase of endodontic treatment. This will help the treating clinician deliver a customized treatment plan to the patient precisely. This case report highlights the variability of the root morphology. It further describes the exact variation in the root canal system of a maxillary second molar, i.e., DB root canal close to the P root canal orifice with partially fused roots. An intraoperative CBCT aided in the better understanding and management of this particular root canal anatomy, followed by the precise execution of the treatment plan.ACKNOWLEDGMENT: None.FUNDING INFORMATION: None.CONFLICT OF INTEREST STATEMENT: The authors declare no conflict of interest related to this publication. This work did not receive any funding.DATA AVAILABILITY STATEMENT: Data related to this paper are available for consultation if requested.PATIENT CONSENT STATEMENT: A written informed consent was obtained from the patient to publish this report in accordance with the journal’s patient consent policy and is in the author’s possession.REFERENCESVertucci FJ. Root canal anatomy of the permanent human teeth. Oral Surg Oral Med Oral Pathol . 1984;58(5):589-599. doi:10.1016/0030-4220(84)90085-9.Martins JNR, Alkhawas MAM, Altaki Z, Bellardini G, Berti L, Boveda C, et al . Worldwide analyses of maxillary first molar second mesiobuccal prevalence: A multicenter cone-beam computed tomographic study. J Endod . 2018;44(11):1641-9.e1. doi:10.1016/j.joen.2018.07.027.Martins JN, Mata A, Marques D, Anderson C, Caramês J. Prevalence and characteristics of the maxillary C-shaped molar. J Endod . 2016;42(3):383-389. doi:10.1016/j.joen.2015.12.013.Martins JN, Mata A, Marques D, Caramês J. Prevalence of root fusions and main root canal merging in human upper and lower molars: A cone-beam computed tomography in vivo study. J Endod . 2016;42:900-908. doi:10.1016/j.joen.2016.03.005.Zhang R, Yang H, Yu X, Wang H, Hu T, Dummer PM. Use of CBCT to identify the morphology of maxillary permanent molar teeth in a Chinese subpopulation. Int Endod J . 2011;44:162-169. doi:10.1111/j.1365-2591.2010.01826.x.Studebaker B, Hollender L, Mancl L, Johnson JD, Paranjpe A. The incidence of second mesiobuccal canals located in maxillary molars with the aid of cone-beam computed tomography. J Endod . 2018;44(4):565-570. doi:10.1016/j.joen.2017.08.026.Martins J. Second mesiobuccal root canal in maxillary molars-A systematic review and meta-analysis of prevalence studies using cone beam computed tomography. Arch Oral Biol. 2019;24:104589. doi:10.1016/j.archoralbio.2019.104589.Kottoor J, Hemamalathi S, Sudha R, Velmurugan N. Maxillary second molar with 5 roots and 5 canals evaluated using cone beam computerized tomography: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod . 2010;109(2):e162-165. doi:10.1016/j.tripleo.2009.09.032.Ahuja P, Ballal S, Velmurugan N. Endodontic management of maxillary second molar with a single root and a single canal diagnosed with cone-beam computed tomography scanning. Saudi Endod J.2012;2(2):100-103.doi:10.4103/1658-5984.108162.Fahid A, Taintor JF. Maxillary second molar with three buccal roots.J Endod. 1988;14(4):181-183. doi:10.1016/S0099-2399(88)80261-9.Suresh M, Karthikeyan K, Mahalaxmi S. Maxillary second molar with fused root and six canals- A case report. J Clin Diagn Res.2017;11:ZD35-ZD37. doi:10.7860/JCDR/2017/25005.9743.Zeng C, Shen Y, Guan X, Wang X, Fan M, Li Y. Rare root canal configuration of bilateral maxillary second molar using cone-beam computed tomographic scanning. J Endod. 2016;42(4):673-677. doi:10.1016/j.joen.2015.12.028.Zmener O, Peirano A. Endodontic therapy in a maxillary second molar with three buccal roots. J Endod. 1998;24(5):376-377. doi: 10.1016/s0099-2399(98)80138-6 .Saeed Asgary. Endodontic treatment of a maxillary second molar with developmental anomaly: A case report. Iran Endod J.2007;2(2):73-76.Zhang Q, Chen H, Fan B, Fan W, Gutmann JL. Root and root canal morphology in maxillary second molar with fused root from a native Chinese population. J Endod . 2014;40(6):871-875. doi:10.1016/j.joen.2013.10.035.Ordinola-Zapata R, Martins JNR, Bramante CM, Villas-Boas MH, Duarte MH, Versiani MA. Morphological evaluation of maxillary second molars with fused roots: a micro-CT study. Int Endod J. 2017;50(12):1192-1200. doi:10.1111/iej.12752.Nagendrababu V, Chong BS, McCabe P, Shah PK, Priya E, Jayaraman J, et al. PRICE 2020 guidelines for reporting case reports in Endodontics: a consensus-based development. Int Endod J . 2020;53(5):619-626.doi: 10.1111/iej.13285.Al-Fouzan KS. C-shaped root canals in mandibular second molars in a Saudi Arabian population. Int Endod J. 2002;5:499–504. doi:10.1046/j.1365-2591.2002.00512.x.Versiani MA, Alves FR, Andrade-Junior CV, Marceliano-Alves MF, Provenzano JC, Rôças IN, et al . Micro-CT evaluation of the efficacy of hard-tissue removal from the root canal and isthmus area by positive and negative pressure irrigation systems. Int Endod J. 2016;49(11):1079-1087. doi:10.1111/iej.12559.Ahmed HMA, Dummer PMH. A new system for classifying tooth, root and canal anomalies. Int Endod J. 2018;51(4):389-404.doi:10.1111/iej.12867.Wu MK, Wesselink PR, Walton RE. Apical terminus location of root canal treatment procedures. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;89(1):99-103. doi:10.1016/S1079-2104(00)80023-2.Han X, Yang H, Li G, Yang L, Tian C, Wang Y. A study of the distobuccal root canal orifice of the maxillary second molars in Chinese individuals evaluated by cone-beam computed tomography. J Appl Oral Sci.2012;20(5):563-567.doi:10.1590/S1678-77572012000500012.Cotti E, Campisi G. Advanced radiographic techniques for the detection of lesions in bone. Endod Topics. 2004;7(1):52-72. doi:10.1111/j.1601-1546.2004.00064.x.Patel S, Brown J, Pimentel T, Kelly RD, Abella F, Durack C. Cone beam computed tomography in Endodontics - a review of the literature.Int Endod J. 2019;52(1):1138-1152. doi:10.1111/j.1601-1546.2004.00064.x.
”A Case of Acute Encephalitis Syndrome and Cranial Nerve Palsy secondary to Scrub Typhus: A Rare Presentation from Western Nepal”.SK Lamichhane1, Eliz Achhami2, Satyam Mahaju3, Rabin Gautam 4, Amrit Adhikari51 Bir Hospital, Kathmandu, Nepal(email:- firstname.lastname@example.org )2 Sukraraj Tropical & Infectious Disease Hospital, Kathmandu, Nepal(email:- email@example.com )3 Sukraraj Tropical & Infectious Disease Hospital, Kathmandu, Nepal(email:- firstname.lastname@example.org )4 Bir Hospital, Kathmandu, Nepal(email:- email@example.com )5 Bir Hospital, Kathmandu, Nepal(email:- firstname.lastname@example.org )*Corresponding author.Eliz Achhami, MBBSSukraraj Tropical & Infectious Disease Hospital, Kathmandu, NepalMobile no. : - 977-9846710319E-mail: email@example.com
INTRODUCTIONParathyroid carcinoma (PC) is a rare endocrine cancer [1,3] and the most uncommon cause of primary hyperparathyroidism (pHPT). It usually induces elevated serum calcium and parathyroid hormone (PTH) levels and the clinical presentation is often characterized by severe symptoms of hypercalcaemia. The diagnosis is not always immediate, especially if there is no evidence of a neck mass which may suggest this kind of disease.The aim of this work is to describe the peculiar clinical presentation of a case of PC and to highlight the importance of suspecting a malignant parathyroid disease in the presence of a pHPT associated with peculiar biochemical and clinical features. The suspicion is essential to perform an adequate intervention at first surgical approach, as which affects the subsequent prognosis.
We describe a 5-year-old child with extrahepatic biliary stone who successfully underwent endoscopic retrograde cholangiopancreatography for stone removal. He suffered from persistent colicky abdominal pain accompanied by fever that biliary stone confirmed him. ERCP along with other methods, can be considered a safe procedure for managing BD in children.
Extracorporeal Membrane Oxygenation as Acute Rescue Therapy for Negative Pressure Pulmonary Edema in the Post Anesthesia Care Unit: A Case ReportKatrina J. Augustin, MD1,*; Christina M. Creel-Bulos, MD1,2; Gaurav F. Budhrani, MD1,3; Casey F. Miller, ANP-BC4 ; Babar Fiza, MD1;1Department of Anesthesiology, Division of Critical Care Medicine, Emory University, Atlanta, GA, USA; 2Department of Emergency Medicine, Emory University, Atlanta, GA, USA;3Anesthesiology Service Line, Atlanta VA Medical Center, Atlanta, GA, USA; 4 Department of Surgery, Division of Cardiothoracic Surgery, Emory University, Atlanta, GA, USA*Corresponding author: Department of Anesthesiology; Emory University; 1364 Clifton Road, NE; Atlanta, GA 30322; +1-404-778-7777;
Cutaneous vasculitis after COVID-19 vaccination in a 41-year-old maleMehran Pournazari1, Shirin Assar1, Faraneh Farsad2, Dena Mohamadzadeh11Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran2 Research Centre of Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Chromosome 4q Deletion Syndrome (4QDS) is a rare chromosomal deletion that presents with various congenital defects that could affect anesthetic management. We present a patient with known 4QDS who underwent successful general anesthetic induction, tracheal intubation, and subsequently, bilateral quadratus lumborum nerve blocks, during laparoscopic inguinal hernia repair surgery.