The tumor of a patient with Bowen’s disease exhibited expression of the tumor suppressors p53 and p16INK4a(p16), which correlated with cytoplasmic expression of the histone deacetylase sirtuin 1(SIRT1). Epigenetic regulation of p53 and p16 by SIRT1 may play a role in the carcinogenesis of Bowen’s disease.
This chext x-ray (CXR) shows a large right sided pneumothorax with a degree mediastinal shift suggesting tensioning (The CXR you should never see!). Furthermore, features of pneumomediastinum are present including the continuous diaphragm sign, and subcutaneous emphysema around the neck and right side of the thorax
Primary thyroid angiosarcoma (TAS) is a rare mesenchymal tumor with poor prognosis, that should be differentiated from anaplastic thyroid carcinoma. We present the 60th case of this rare tumor and highlight the importance of early diagnosis, undelayed surgery and complementary radiation in order to improve prognosis and overall survival.
Bone hemangiomas are extremely rare benign tumors. We hereby present a case of 41-year old woman, that had a sever thyrotoxicosis, associated with severe GO which has necessitated glucocorticoid treatment. A link between hemangioma and sever thyrotoxicosis and/or IV GC might have resulted in endothelial alterations, and/or bone loss.
Intraprosthetic regurgitation (IR) is a rare but devastating complication of transcatheter aortic valve implantation (TAVI). We describe the successful treatment of moderate intraprosthetic regurgitation in a 89 year old woman, who had been treated for severe aortic stenosis using a 23mm SAPIEN-3 valve.
A 61-year-old woman who has undergone coronary artery bypass grafting 30 years ago, now reveals severe mitral regurgitation. Coronary angiography and computed tomography show patency of the graft. To avoid injuring the graft, mitral valve replacement under ventricular fibrillation without aortic cross clamping was performed through a right minithoracotomy approach.
Here we report a case of advanced extranodal natural killer/T cell lymphoma (ENKTL) in 11-year-old child. Positron emission tomography-magnetic resolution image is a crucial image to diagnose ENKTL in this case. Additionally, a strong regime combined with stem cell transplantation possibly improve prognosis of ENKTL.
In up to 10 % of patients with hypertrophic cardiomyopathy, the disease is caused by genetic disorders including metabolic diseases. Sometimes clinical workup may be confusing. To our knowledge, this is the first report of false positive results of scintigraphy indicating cardiac amyloidosis in a patient with Danon disease.
Aberrant common hepatic artery originating from the left gastric artery without connecting the gastroduodenal artery is extremely rare. In gastrectomy, accidental ligation or injury of the aberrant common hepatic artery can lead to hepatic arterial ischemia. Reconstructions of CT images may be useful to avoid complications related to vascular anomaly.
A 30-year-old female with clinical manifestations of palpitations and goiter was admitted to our department of endocrinology. Laboratory tests showed elevated thyroid hormone with non-suppressed TSH. Genetic analysis identified heterozygous mutation of the THRB exon10 c.G1378A (p.E460K). The proband’s kindreds had the same mutation, but their clinical manifestations were different.
The kidneys are normally blooded from renal artery that anatomically originates from the abdominal aorta. However, there are accessory polar artery variations. Incidence varies ranges from 11.3% to 59.5% depending on ethnicity. We also wanted to show two different cases of accessory polar renal artery (APRA).
Transfusion Related Acute Lung Injury (TRALI) has been associated with neutrophil reacting antibodies in transfused blood products. We report a case of life threatening TRALI in an obstetric patient triggered by transfusion from a non-transfused male blood donor. A residual risk of TRALI exist, even in a male-only plasma setting.
Nasal packing constitutes a common step in nasal procedures. A correct fixation is of uttermost importance to avoid posterior dislocation and aspiration. This case report highlights the risk of acute airway situations involving nasal packs and discuses common errors that should be avoided to prevent this life-threatening complication.
Differentiating plasmablastic lymphoma and plasmablastic myeloma is challenging due to overlapping morphological and immunophenotypical features. This case demonstrates the difficulty to distinguish a non-secretor myeloma with plasmablastic morphology from a plasmablastic lymphoma and the necessity of a multidisciplinary approach to make an accurate diagnosis because the treatment protocols are different.