We report a rare and first case of combined cerebral venous sinus thrombosis and posterior internal carotid artery stroke in a 35-year-old female on combined oral contraceptive pills (COCP), presented with headache and vertigo, found to have extensive venous thrombosis and PICA territory ischemic infarct with persistently elevated factor VIII.
In this paper, we combine the sinc and self-consistent methods to solve a class of non-linear eigenvalue differential equations. Some properties of the self-consistent and sinc methods required for our subsequent development are given and employed. Numerical examples are included to demonstrate the validity and applicability of the introduced technique and a comparison is made with the existing results. The method is easy to implement and yields accurate results. We show that the sinc-self-consistent method can solve the equations on an infinite domain and produces the smallest eigenvalue with the most accuracy
Three-dimensional sealing and disinfecting is a very difficult challenge in the canals affected by internal resorption. Hybrid irrigation is a method that takes advantage of both ultrasonic / sonic activations, which has previously proven effective in cleaning the root canals. Also, modern biological materials are suitable to seal these canals.
Abstract Objective: To summarize the risk prediction models of chronic disease in Chinese medicine, describe their performance, and assess suitability of clinical or administrative use. Methods: The China National Knowledge Infrastructure and Wanfang Data were searched through February 2021, and hand searches were performed of the retrieved reference lists. Dual review was conducted to identify studies of prediction models of chronic disease in Chinese medicine. Results: From 399 citations reviewed, 17 studies were included in the analysis. Most of the studies were from single-centers (50%) or did not external validated (81.25%). The sample sizes were smaller and the models’ discrimination were larger compared with studies in fully western medicine. All the models used both laboratory findings and subjective judgements from doctors or patients. 9 models concentrated on diabetes mellitus or cardiovascular disease, and showed better performance and clinical application. Conclusions: The prediction models of chronic disease in Chinese medicine have unique advantages due to their considerations of doctors’ and patients’ subjective judgement. Diabetes mellitus and cardiovascular disease prediction models were in higher quality and clinical usability. Efforts to improve their quality are needed as use becomes more widespread.
A 72-year-old female used the oral phosphate binder lanthanum carbonate for 6 years, before discontinuing it after receiving a pancreas and kidney transplant. Now, 7 years after discontinuation, the patient developed bilious emesis. An upper gastrointestinal endoscopy showed an unspecific gastritis. Biopsies showed subepithelial crystalline deposits consistent with gastric lanthanosis.
ACE-2 receptor plays a vital role not only in the SARS-CoV-induced epidemic but also in some diseases. Studies have been carried out on the interactions of ACE-2- SARS-CoV proteins. However, comprehensive research has not been conducted on ACE2 protein by using bioinformatic tools. The present study especially two places, G104 and L108 points, which are effective in protecting the structure of the ACE-2 protein, play a critical role in the biological functioning of this protein, and play an essential role in determining the chemical-physical properties of this protein, and play a crucial role for ACE-2 protein-SARS CoV surface glycoprotein, were determined. It was also found that the G104 and L108 regions were more prone to possible mutations or deletions than the other ACE-2 protein regions. Moreover, it was determined that all possible mutations or deletions in these regions affect the chemical-physical properties, biological functions, and structure of the ACE-2 protein. Having a negative GRAVY value, one transmembrane helix, a significant molecular weight, a long-estimated half-life as well as most having unstable are results of G104 and L108 points mutations or deletions. Finally, it was determined that LQQNGSSVLS, which belong to the ACE-2 protein, may play an active role in binding the spike protein of SARS-CoV. All possible docking score results were estimated. It is thought that this study will bring a different perspective to ACE-2 _SARS-CoV interaction and other diseases in which ACE-2 plays an important role and will also be an essential resource for studies on ACE-2 protein.
Objective The aim of this project was to identify gaps and research waste in the dissemination of fertility evidence in the Cochrane database of systematic reviews (CDSR). Design A research article. Setting The Cochrane Gynaecology and Fertility (CGF) Group’s specialised register of random controlled trials (RCTs). Sample Infertility trials contained in the CGF specialised register, published between the years 2010-2011. Methods Infertility trials from the CGF specialised register were matched, by the specific fertility issue and treatment, to existing Cochrane reviews. Unmatched trials were categorised to develop and prioritise new review topics. Main outcome measures Proportions Results 564 trials, published from 2010 to 2011, were exported from the specialised register and after removing duplicates, 318 trials were found to be already included in a Cochrane review. 187 (37%) of trials were found to be unused, however 115 (23%) of these could be included in an existing CGF SR, if it were updated. 72 trials (14%) were not matched to any review topic and from these, eight new Cochrane review titles were developed. The topic with the largest number of associated ‘unused’ trials, was ‘Traditional Chinese Medicine for women undergoing assisted reproductive techniques’. Conclusions This project was used to consider unused trials, prioritise new review topics and identify those reviews that need to be updated, thereby identifying the gaps in evidence for couples with fertility problems. Keywords research waste, gaps, fertility, infertility, randomized controlled trials, systematic reviews, prioritisation.
Structural variations (SVs) have been associated with genetic diversity and adaptation in diverse taxa. Despite these observations, it is not yet clear what their relative importance is for microevolution, especially with respect to known drivers of diversity, e.g., nucleotide substitutions, in rapidly adapting species. Here we examine the significance of SVs in pesticide resistance evolution of the agricultural super-pest, the Colorado potato beetle, Leptinotarsa decemlineata. By employing a trio-binning procedure, we develop near chromosomal reference genomes to characterize structural variation within this species. These updated assemblies represent >100-fold improvement of contiguity and include derived pest and ancestral non-pest individuals. We identify >200,000 SVs, which appear to be non-randomly distributed across the genome as they co-occur with transposable elements. SVs intersect exons for genes associated with insecticide resistance, development, and transcription, most notably cytochrome P450 (CYP) genes. To understand the role that SVs might play in adaptation, we incorporate an additional 66 genomes among pest and non-pest populations of North America into the SV graph. Single nucleotide polymorphisms (SNPs) and SVs have a similar proportion in coding and non-coding regions of the genome, but there is a deficit of SNPs in SVs, suggesting SVs may be under selection. Using multiple lines of evidence, we identify 28 positively selected genes that include 337 SVs and 442 outlier SNPs. Among these, there are four associated with insecticide resistance. Two of these genes (CYP4g15 and glycosyltransferase-13) are physically linked by a structural variant and have previously been shown to be co-induced during insecticide exposure.
Diversity-stability relationships in grasslands depend on the environment. Climate change and soil degradation potentially alter soil pH and community stability within grassland environments, although it remains unclear how soil acidity and alkalinity affect diversity-stability relationships. We conducted a three-year experiment of acidification and alkalization treatments in an arid grassland in northern China, and found that increasing and decreasing soil pH reduced community species richness, community diversity, community and dominant species asynchrony, and biomass stability. Soil acidification reduced community stability by reducing dominant species stability. Soil alkalization reduced community stability by reducing species asynchrony and dominant species stability. Acidification significantly enhanced the availabilities of soil NO3—N, P, and K, but did not affect the concentrations of soil total C, N, and P. By contrast, alkalization significantly reduced soil total C and N, but did not affect the availabilities of soil N, P, and K. Structural equation model analysis revealed that altered soil pH affected soil nutrients associated with species asynchrony and community stability, which indicated the importance of soil nutrients in driving community stability. Our results suggest that soil pH–mediated community stability is mainly driven by dominant species stability rather than diversity. This study provides novel insights indicating that arid grassland stability would be weakened under changing soil pH, subsequently leading to land degradation and reducing long‐term productivity and sustainability.
Cutis Vertcis gyrata is an uncommon neurocutaneous syndrome characterized by excessive growth of the skin of the scalp or the face, forming folds of similar aspect to cerebral cortex gyri. Three categories have been individualized: the primary form, essential or non-essential, and the secondary form.
Euglycemic DKA (EKDA) is a variant of DKA. In this case report, we discuss the course of COVID-19 infection in a pregnant woman with gestational diabetes who developed severe euglycemic diabetic ketoacidosis triggered by various precipitating factors, including starvation, caused by Covid-19 infection and its gastrointestinal effects.
Objectives: Pleuropulmonary blastoma (PPB) is a very rare, characteristic and highly aggressive neoplasm occurring in children, most under 6 years of age. We assessed the clinical characteristics, treatment modalities, treatment outcomes, and prognostic factors affecting survival in patients with PPB treated at our institution over a 10-year period to improve the prognosis of PPB. Methods: From November 2008 to November 2019, 31 children (21 boys and 10 girls) with a median age of 30 months (range, 22 days-54 months) were treated at our institution. Here, we describe the patient characteristics, treatment modalities and treatment outcomes. The Kaplan-Meier method was used to estimate the progression free survival probability (PFS) and overall survival (OS). Log-rank test was performed for comparison between groups. Results: 3 children were lost to follow-up and 2 were dead of postoperative complications. Of the 26 patients included in the follow-up, 16 PPB patients displayed tumor-free survival. The 6-month, 1-, 3-, and 5-year PFS were 80.8%, 69.0%, 60.4% and 60.4%, respectively. Accordingly, the 6-month, 1-, 3-, and 5-year OS were 84.6%, 72.7%, 60.1% and 60.1%, respectively. Sex, extent of surgery and chemotherapy/irradiation appeared to affect the survival, while age and pathology type appeared not to do. Conclusions: PPB is an aggressive neoplasm. To improve the prognosis of PPB, we should promote radical resection and improve the auxiliary treatment measures.
Barekot rural municipality of Jajarkot district is an Important Bird Areas (IBAs) in Western Nepal. In recent years, illegal hunting and trapping-related cases have increased in this area. Additionally, a hydropower project with a capacity of 410 MW is being constructed within Barekot. The present study aims to update the preliminary checklist of birds and identify the underlying threats to the bird population in this region. Bird survey was conducted in four monitoring blocks of Barekot during the late winter of 2021. Also, a series of consultation meetings and interviews with the local stakeholders were organized to collect information regarding the extant threats. This study revealed eighty-seven bird species of 10 orders and 34 families. Birds most commonly recorded from the family Muscicapidae and order Passeriformes. Among the total recorded species, two species are listed in the IUCN Red List of Nationally Vulnerable Category. Similarly, five species were listed on CITES Appendix II and one species on CITES Appendix I. Approximately 82% of total bird species were of resident type. Despite a decline in bird diversity, Barekot’s unique geographical location still makes it an important IBA in Nepal. Bird numbers have plummeted due to human intrusion and disturbance, and natural system modifications. Based on our findings, we recommend landscape-level research, on the impacts of hydropower projects, roads, poaching, and impacts of the Covid-19 pandemic. Similarly, future conservation efforts should also emphasize preventing habitat fragmentation and raising public awareness. Keywords: Avian community; Bird checklist; Important Bird Area; Threats
Phase transitions between ordered and disordered states of interactive agents have been recognized as integral to dynamics in a range of economic and social processes. Several theorists in the study of financial markets have directly linked phase transitions between disordered and ordered states of agents to a critical point in the dynamics of market price. To date, phase transitions in the dynamics of price in financial markets have been demonstrated with numerical methods. In an application to a financial market, we propose a multicomponent in which a first component is in bounded rationality and a second component is in behavior that generates herding in financial markets. A transition function defines the relative weight of components. We extend conditions of Onsager (1944) for phase transitions in a 2D Ising model and analytically demonstrate that the proposed model evidences phase transitions. Generalizations of the results to other multi-component models are noted.
Background: This study aimed to investigate the risk factors for smoking and negative perinatal outcomes among Jordanian women about smoking status. Methods: A case-control study was conducted among singleton full-term pregnant women who gave birth at the main hospital in Jordan in June 2020. They were divided into three groups according to their smoking status (active, passive and non-smokers) and were interviewed using a semi-structured questionnaire, including demographic information, current pregnancy history, perinatal and neonatal outcomes. The study investigated the effect of smoking status on both independent and dependent variables. Results: Our study revealed that low-level maternal education (OR=25.38), unemployed maternal status (OR=2.67), the absence of following up during pregnancy (OR=5.8), smoking husband were risk factors for smoke exposure among pregnant women. The risk for cesarean section was increased in nulliparous smoking women (OR=9.0), those with low family monthly income (OR=7.8), and those who did not get any information about the hazard effect of smoking (OR=4.38), as well as in unemployed passive smoking women (OR=6.25). Parity of more than one has raised the risk of NICU admission inactive smoking women (OR=10.38). This risk was also increased in active and passive women with a lower level of education (OR=186.33 and OR=17.5), respectively, as well as inactive smoking women with low family monthly income (OR=4.11). Conclusions: Appropriate preventive strategies should focus on modifiable risk factors for smoking during pregnancy.
INTRODUCTION: Inflammatory bowel disease (IBD) is a non-specific chronic inflammatory disease. Previous studies confirmed that inflammation plays an important role and red blood cell distribution width (RDW) is related to the activity of IBD. OBJECTIVES: To identify the prognosis value of RDW in the intestinal resection of IBD. PATIENTS AND METHODS: A total of 366 patients were included in this retrospective analysis, diagnosed with IBD between March 2012 and November 2014 in the Sixth Affiliated Hospital of Sun Yat-Sen University. All participants were followed up at least 5years. Patients’ demographic characteristics and laboratory data were obtained from medical record within 24h at first hospitalization. We compared the clinical features in the intestinal resection and non-intestinal resection groups. Kaplan–Meier estimates of the probability of intestinal resection post-admission time were computed, and compared with log-rank test according to stratification of RDW value. RESULTS: There were 93 patients in the intestinal resection group and 273 in the non- intestinal resection group. Significant higher RDW values were detected in the intestinal resection group (P<0.001). RDW was obviously related to indicators such as C-reactive protein (p=0.008). Univariate Cox regression analysis demonstrated that IBD type (Crohn’s disease or ulcerative colitis) (P<0.001), RDW (P<0.001), C-reactive protein (P<0.001) and others were associated with intestinal resection probability. But only RDW [OR: 1.088 (95% CI 1.009-1.173), P=0.03] and IBD type (P=0.001) were independent predictors. CONCLUSIONS: RDW and IBD type were independent predictors of intestinal resection in IBD. KEY WORDS: inflammatory bowel disease, intestinal resection, red blood cell distribution width