ITQB Preprint Journal Club: 9 Nov 2017
Metabolic Interactions Between Dynamic Bacterial Subpopulations Adam Z Rosenthal, Yutao Qi, Sahand Hormoz, Jin Park, Sophia Hsin-Jung Li, Michael ElowitzVersion reviewed: V1. October 25, 2017. bioRxiv 208686; doi: https://doi.org/10.1101/208686Note: This review incorporates input from attendees to the ITQB Preprint Journal Club on November 9, 2017.Overview:Rosenthal et al. demonstrate that stochastic changes between metabolic gene expression states underlie the population-averaged progression through acetate production to acetoin detoxification during exponential growth of B. subtilis. They show that the probabilities of cells being in the slow-growing, acetate-producing (sucC+) and acetoin-producing (alsS+) states depend upon competence regulators (comK) as well as environmental acetate concentration. The work combines population averaged experiments with single-cell fluorescence snapshot and timelapse microscopy experiments to conclusively prove the claims in the abstract. The work was very interesting for members of our journal club coming from several different fields. We were particularly interested in the the implications of the final gel-pad timelapse experiment and its discussion in the main text—the possibility that competence, toxic-product secretion, and subsequent detoxification could be coupled to give B. subtilis an advantage in a complex environment will be a great problem to investigate in the future.
MozFest 2017 Session– Changing the scientific publishing ecosystem: preprints and beyond
The following notes were taken by Naomi Penfold, eLIFE Innovation Officer, during our session at MozFest 2017. Here is a link to our short slide deck. Welcome everyone! We are excited to see you and we hope you are having a fantastic time at MozFest 2017. Who are we?* Daniela Saderi, neuroscientist at OHSU. I love organising community events, including Science Hack Day Portland. Originally from Sardinia (it's beautiful!)* Samantha Hindle, "post"-postdoc at UCSF, from scarborough, UK. I'm a neuroscientist too.We are ASAPbio ambassadors! We advocate for preprints in the life sciences, and have built PREreview to enable researchers to review preprints in their journal clubs and online.* Naomi Penfold, eLife - I'm here to help Dani and Sam to encourage the adoption of preprints.
PREreview Journal Club - InBio Journal Club at IBIS - 27 OCT 2017
[Compensatory evolution via cryptic genetic variation: Distinct trajectories to phenotypic and fitness recovery] [Sudarshan Chari, Christian Marier, Cody Porter, Emmalee Northrop, Alexandra Belinky and Ian Dworkin , october 10, 2017, version 1, BioRXiv]
Systems JC, OHSU - PREreview of "Age-related decline in behavioral discrimination of amplitude modulation frequencies compared to envelope-following responses"
This is a preprint journal club review of "Age-related decline in behavioral discrimination of amplitude modulation frequencies compared to envelope-following responses"
by Jesyn Lay, Edward L. Bartlett. The preprint was posted on bioRxiv on Sep 28, 2017 (DOI: http://dx.doi.org/10.1101/193268
Our group reviewed this paper on October 13, 2017 and used the PREreview quick participant worksheet.
Systems JC, OHSU - PREreview of "Cortical Representations of Speech in a Multi-talker Auditory Scene"
This is a preprint journal club review of Cortical Representations of Speech in a Multi-talker Auditory Scene by Krishna C Puvvada, Jonathan Z Simon. The preprint was originally posted on bioRxiv on April 10, 2017 (DOI: https://doi.org/10.1101/124750). The authors have responded to this review, and you can find the comments on bioRxiv. The article is now published in The Journal of Neuroscience (DOI: 10.1523/JNEUROSCI.0938-17.2017).