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A Narrative Review on Therapeutic Potential of Naringenin in Colorectal Cancer: Focusing on molecular and biochemical processes
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  • Mohammad Yasin Zamanian,
  • Maryam Golmohammadi,
  • Bekhzod Abdullaev,
  • María Olalla García,
  • Adeeb Abdulally Abdulhussien Alazbjee,
  • Abhinav Kumar,
  • Sameer S. Mohaamed,
  • Beneen M. Hussien,
  • Fattaneh Khalaj,
  • Seyede Mahsa Hodaei,
  • Niyousha Shirsalimi,
  • Gervason Moriasi
Mohammad Yasin Zamanian
Hamadan University of Medical Sciences Medical School

Corresponding Author:[email protected]

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Maryam Golmohammadi
Shahid Beheshti University of Medical Sciences School of Medicine
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Bekhzod Abdullaev
Asian Development Bank Uzbekistan Resident Mission
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María Olalla García
Universidad Internacional del Ecuador Facultad de Ciencias Medicas de la Salud y de la Vida
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Adeeb Abdulally Abdulhussien Alazbjee
Thi Qar University College of Medicine
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Abhinav Kumar
Ural'skij federal'nyj universitet imeni pervogo Prezidenta Rossii B N El'cina Institut novyh materialov i tehnologij
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Sameer S. Mohaamed
Al Safwa University College Department of Pharmacy
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Beneen M. Hussien
The Islamic University Medical Laboratory Technology Department
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Fattaneh Khalaj
Shariati Hospital
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Seyede Mahsa Hodaei
Arak University of Medical Sciences
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Niyousha Shirsalimi
Hamadan University of Medical Sciences Medical School
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Gervason Moriasi
Mount Kenya University College of Health Sciences
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Colorectal cancer (CRC) is a common and highly metastatic cancer affecting people worldwide. Drug resistance and unwanted side effects are some of the limitations of current treatments for CRC. Naringenin (NAR) is a naturally occurring compound found in abundance in various citrus fruits such as oranges, grapefruits, and tomatoes. It possesses a diverse range of pharmacological and biological properties that are beneficial for human health. Numerous studies have highlighted its antioxidant, anti-cancer, and anti-inflammatory activities, making it a subject of interest in scientific research. This review provides a comprehensive overview of the effects of NAR on CRC. The study’s findings indicated that NAR: 1) interacts with estrogen receptors, 2) regulates the expression of genes related to the p53 signaling pathway, 3) promotes apoptosis by increasing the expression of proapoptotic genes (Bax, caspase9, and p53) and downregulation of the antiapoptotic gene Bcl2, 4) inhibits the activity of enzymes involved in cell survival and proliferation, 5) decreases cyclin D1 levels, 6) reduces the expression of cyclin-dependent kinases (Cdk4, Cdk6, Cdk7) and anti-apoptotic genes (Bcl2, x-IAP, c-IAP-2) in CRC cells. In vitro CDK2 binding assay was also performed, showing that the NAR derivatives had better inhibitory activities on CDK2 than NAR. Based on the findings of this study, NAR is a potential therapeutic agent for CRC. Additional pharmacology and pharmacokinetics studies are required to fully elucidate the mechanisms of action of NAR and establish the most suitable dose for subsequent clinical investigations.
06 Mar 2024Submitted to Cell Biochemistry & Function
06 Mar 2024Review(s) Completed, Editorial Evaluation Pending
06 Mar 2024Reviewer(s) Assigned
21 Mar 2024Editorial Decision: Revise Major
28 Mar 2024Review(s) Completed, Editorial Evaluation Pending
31 Mar 2024Editorial Decision: Accept