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Advanced three-dimensional in vitro liver models to study the activity of anticancer drugs
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  • Agnieszka Zuchowska,
  • Sonia Frojdenfal,
  • Maciej Trzaskowski,
  • Elzbieta Jastrzebska
Agnieszka Zuchowska
Warsaw University of Technology

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Sonia Frojdenfal
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Maciej Trzaskowski
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Elzbieta Jastrzebska
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The liver is one of the most important organs in the human body. It performs many important functions, including being responsible for the metabolism of most drugs, which is often associated with its drug-induced damage. Currently, there are no ideal pharmacological models that would allow the evaluation of the effect of newly tested drugs on the liver in preclinical studies. Moreover, the influence of hepatic metabolism on the effectiveness of the tested drugs is rarely evaluated. Therefore, in this work we present an advanced model of the liver, which reflects most of the morphologically and metabolically important features of the liver in vivo, namely: three-dimensionality, cellular composition, presence of extracellular matrix, distribution of individual cell types in the structure of the liver model, high urea and albumin synthesis efficiency, high cytochrome p450 activity. In addition, the work, based on the example of commonly used anticancer drugs, shows how important it is to take into account hepatic metabolism in the effective assessment of their impact on the target organ, in this case cancer.
13 Mar 2024Submitted to Biotechnology Journal
19 Mar 2024Assigned to Editor
19 Mar 2024Submission Checks Completed
20 Mar 2024Reviewer(s) Assigned
03 Apr 2024Review(s) Completed, Editorial Evaluation Pending
03 Apr 2024Editorial Decision: Revise Major